Details of the Target

General Information of Target

Target ID LDTP11742
Target Name RNA-binding protein 38 (RBM38)
Gene Name RBM38
Gene ID 55544
Synonyms
RNPC1; SEB4; RNA-binding protein 38; CLL-associated antigen KW-5; HSRNASEB; RNA-binding motif protein 38; RNA-binding region-containing protein 1; ssDNA-binding protein SEB4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEDEFIGEKTFQRYCAEFIKHSQQIGDSWEWRPSKDCSDGYMCKIHFQIKNGSVMSHLG
ASTHGQTCLPMEEAFELPLDDCEVIETAAASEVIKYEYHVLYSCSYQVPVLYFRASFLDG
RPLTLKDIWEGVHECYKMRLLQGPWDTITQQEHPILGQPFFVLHPCKTNEFMTPVLKNSQ
KINKNVNYITSWLSIVGPVVGLNLPLSYAKATSQDERNVP
Target Bioclass
Other
Family
RBM38 family
Subcellular location
Cytoplasm, cytosol
Function
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.; (Microbial infection) Essential factor for the splicing of the pre-mRNAs of human parvovirus B19 (B19V) and for the expression of B19V 11-kDa protein, which enhances viral replication.
Uniprot ID
Q9H0Z9
Ensemble ID
ENST00000356208.10
HGNC ID
HGNC:15818

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MM1S SNV: p.E89D .
NCIH1792 SNV: p.T173A .
OVCAR5 SNV: p.G40A .
SUDHL6 SNV: p.Y53Ter .
TE11 SNV: p.R16G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K35(2.12)  LDD2218  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]
1d-yne
 Probe Info  		N.A.  LDD0356  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Zinc finger CCCH domain-containing protein 10 (ZC3H10) . Q96K80

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.