Details of the Target

General Information of Target

Target ID LDTP11668
Target Name Nuclear RNA export factor 2 (NXF2; NXF2B)
Gene Name NXF2; NXF2B
Gene ID 56001
Synonyms
TAPL2; Nuclear RNA export factor 2; Cancer/testis antigen 39; CT39; TAP-like protein 2; TAPL-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLHYVAVLTLAILMFLTWLPESLSCNKALCASDVSKCLIQELCQCRPGEGNCSCCKECM
LCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVS
FPVAEELSHHENLVSFLETVNQPHHQNVSVPSNNVHAPYSSDKEHMCTVVYFDDCMSIHQ
CKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNCMF
Target Bioclass
Other
Family
NXF family
Subcellular location
Nucleus, nucleoplasm
Function Involved in the export of mRNA from the nucleus to the cytoplasm.
Uniprot ID
Q9GZY0
Ensemble ID
ENST00000602195.6
HGNC ID
HGNC:8072

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C165(2.40)  LDD3331  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C165(2.00)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C165(2.69)  LDD2660  [2]
 LDCM0024  KB05 MKN-1 C165(2.40)  LDD3331  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-hexosaminidase subunit beta (HEXB) Glycosyl hydrolase 20 family P07686

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840