Details of the Target

General Information of Target

Target ID LDTP11664
Target Name Zinc finger protein 350 (ZNF350)
Gene Name ZNF350
Gene ID 59348
Synonyms
ZBRK1; Zinc finger protein 350; KRAB zinc finger protein ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; Zinc finger protein ZBRK1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWLPRVSSTAVTALLLAQTFLLLFLVSRPGPSSPAGGEARVHVLVLSSWRSGSSFVGQLF
NQHPDVFYLMEPAWHVWTTLSQGSAATLHMAVRDLVRSVFLCDMDVFDAYLPWRRNLSDL
FQWAVSRALCSPPACSAFPRGAISSEAVCKPLCARQSFTLAREACRSYSHVVLKEVRFFN
LQVLYPLLSDPALNLRIVHLVRDPRAVLRSREQTAKALARDNGIVLGTNGTWVEADPGLR
VVREVCRSHVRIAEAATLKPPPFLRGRYRLVRFEDLAREPLAEIRALYAFTGLSLTPQLE
AWIHNITHGSGPGARREAFKTSSRNALNVSQAWRHALPFAKIRRVQELCAGALQLLGYRP
VYSEDEQRNLALDLVLPRGLNGFTWASSTASHPRN
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.
Uniprot ID
Q9GZX5
Ensemble ID
ENST00000243644.9
HGNC ID
HGNC:16656

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C332(1.24)  LDD3395  [1]
IA-alkyne
 Probe Info  		C332(7.00)  LDD1703  [2]
Acrolein
 Probe Info  		N.A.  LDD0227  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell C332(7.00)  LDD1703  [2]
 LDCM0023  KB03 A101D C332(3.54)  LDD2667  [1]
 LDCM0024  KB05 PC-3 C332(1.24)  LDD3395  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer type 1 susceptibility protein (BRCA1) . P38398

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.