Details of the Target
General Information of Target
| Target ID | LDTP11655 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ankyrin repeat domain-containing protein 2 (ANKRD2) | |||||
| Gene Name | ANKRD2 | |||||
| Gene ID | 26287 | |||||
| Synonyms |
ARPP; Ankyrin repeat domain-containing protein 2; Skeletal muscle ankyrin repeat protein; hArpp |
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| 3D Structure | ||||||
| Sequence |
MDGGDDGNLIIKKRFVSEAELDERRKRRQEEWEKVRKPEDPEECPEEVYDPRSLYERLQE
QKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELIEKQRREEELKELKEYRNNLK KVGISQENKKEVEKKLTVKPIETKNKFSQAKLLAGAVKHKSSESGNSVKRLKPDPEPDDK NQEPSSCKSLGNTSLSGPSIHCPSAAVCIGILPGLGAYSGSSDSESSSDSEGTINATGKI VSSIFRTNTFLEAP |
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasm, myofibril, sarcomere, I band
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| Function |
Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
5E-2FA Probe Info |
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N.A. | LDD2235 | [1] | |
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m-APA Probe Info |
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N.A. | LDD2231 | [1] | |