Details of the Target

General Information of Target

Target ID LDTP11633
Target Name Platelet-derived growth factor D (PDGFD)
Gene Name PDGFD
Gene ID 80310
Synonyms
IEGF; SCDGFB; Platelet-derived growth factor D; PDGF-D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form; PDGFD latent form; Platelet-derived growth factor D, receptor-binding form; PDGFD receptor-binding form)]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MATVMAATAAERAVLEEEFRWLLHDEVHAVLKQLQDILKEASLRFTLPGSGTEGPAKQEN
FILGSCGTDQVKGVLTLQGDALSQADVNLKMPRNNQLLHFAFREDKQWKLQQIQDARNHV
SQAIYLLTSRDQSYQFKTGAEVLKLMDAVMLQLTRARNRLTTPATLTLPEIAASGLTRMF
APALPSDLLVNVYINLNKLCLTVYQLHALQPNSTKNFRPAGGAVLHSPGAMFEWGSQRLE
VSHVHKVECVIPWLNDALVYFTVSLQLCQQLKDKISVFSSYWSYRPF
Target Type
Literature-reported
Target Bioclass
Other
Family
PDGF/VEGF growth factor family
Subcellular location
Secreted
Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.
TTD ID
T90464
Uniprot ID
Q9GZP0
DrugMap ID
TTSN0GA
Ensemble ID
ENST00000302251.9
HGNC ID
HGNC:30620

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.I214LfsTer68 .
CHL1 SNV: p.D20N .
FADU SNV: p.R262G .
HG3 SNV: p.P198S .
HT115 SNV: p.R247Ter .
MCC13 SNV: p.E103K .
RKO SNV: p.R34C .
TOV21G Deletion: p.I214LfsTer68 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		S22(0.00); S27(0.00); S29(0.00); T21(0.00)  LDD0245  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tandutinib Small molecular drug DB05465
Cr002 . DB05139

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.