Details of the Target

General Information of Target

Target ID LDTP11631
Target Name Brain-specific serine protease 4 (PRSS22)
Gene Name PRSS22
Gene ID 64063
Synonyms
BSSP4; PRSS26; Brain-specific serine protease 4; BSSP-4; EC 3.4.21.-; Serine protease 22; Serine protease 26; Tryptase epsilon
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDSDLGEDEGLLSLAGKRKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNL
SVLQICNWFINARRRLLPDMLRKDGKDPNQFTISRRGGKASDVALPRGSSPSVLAVSVPA
PTNVLSLSVCSMPLHSGQGEKPAAPFPRGELESPKPLVTPGSTLTLLTRAEAGSPTGGLF
NTPPPTPPEQDKEDFSSFQLLVEVALQRAAEMELQKQQDPSLPLLHTPIPLVSENPQ
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function Preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.
Uniprot ID
Q9GZN4
Ensemble ID
ENST00000161006.8
HGNC ID
HGNC:14368

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C139(1.46)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX390 C139(1.85)  LDD2273  [1]
 LDCM0023  KB03 BRX211 C139(1.44)  LDD2685  [1]
 LDCM0024  KB05 IGR37 C139(1.46)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840