Details of the Target

General Information of Target

Target ID LDTP11624
Target Name STE20-related kinase adapter protein beta (STRADB)
Gene Name STRADB
Gene ID 55437
Synonyms
ALS2CR2; ILPIP; STE20-related kinase adapter protein beta; STRAD beta; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; ILP-interacting protein; Pseudokinase ALS2CR2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASR
VGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVICPAVLQQLNFHPCEDRPKHK
TRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPKILTFFVGLAIGTLFSNAIFQ
LIPEAFGFDPKVDSYVEKAVAVFGGFYLLFFFERMLKMLLKTYGQNGHTHFGNDNFGPQE
KTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSVVSLQDGKKEPSSCTCLKGPKLSEI
GTIAWMITLCDALHNFIDGLAIGASCTLSLLQGLSTSIAILCEEFPHELGDFVILLNAGM
STRQALLFNFLSACSCYVGLAFGILVGNNFAPNIIFALAGGMFLYISLADMFPEMNDMLR
EKVTGRKTDFTFFMIQNAGMLTGFTAILLITLYAGEIELE
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Subcellular location
Nucleus
Function
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.
Uniprot ID
Q9C0K7
Ensemble ID
ENST00000194530.8
HGNC ID
HGNC:13205
ChEMBL ID
CHEMBL4105756

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1954 Insertion: p.S111KfsTer7 .
HEC1 SNV: p.P284H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C406(1.04)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C406(1.04)  LDD1507  [1]
 LDCM0276  AC17 HEK-293T C406(0.99)  LDD1515  [1]
 LDCM0285  AC25 HEK-293T C406(1.12)  LDD1524  [1]
 LDCM0294  AC33 HEK-293T C406(1.01)  LDD1533  [1]
 LDCM0303  AC41 HEK-293T C406(1.00)  LDD1542  [1]
 LDCM0311  AC49 HEK-293T C406(0.94)  LDD1550  [1]
 LDCM0320  AC57 HEK-293T C406(0.77)  LDD1559  [1]
 LDCM0356  AKOS034007680 HEK-293T C406(0.96)  LDD1570  [1]
 LDCM0404  CL17 HEK-293T C406(0.66)  LDD1608  [1]
 LDCM0417  CL29 HEK-293T C406(0.90)  LDD1621  [1]
 LDCM0431  CL41 HEK-293T C406(1.03)  LDD1635  [1]
 LDCM0440  CL5 HEK-293T C406(1.32)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C406(0.93)  LDD1647  [1]
 LDCM0457  CL65 HEK-293T C406(1.13)  LDD1660  [1]
 LDCM0470  CL77 HEK-293T C406(0.93)  LDD1673  [1]
 LDCM0483  CL89 HEK-293T C406(0.95)  LDD1686  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402