Details of the Target

General Information of Target

Target ID LDTP11622
Target Name B-cell lymphoma/leukemia 11B (BCL11B)
Gene Name BCL11B
Gene ID 64919
Synonyms
CTIP2; RIT1; B-cell lymphoma/leukemia 11B; BCL-11B; B-cell CLL/lymphoma 11B; COUP-TF-interacting protein 2; Radiation-induced tumor suppressor gene 1 protein; hRit1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSMKRDDTKDTYKLPHRLIEKKRRDRI
NECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSL
KSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHAVATQFLPTPQLL
TQQVPLSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQPSAELAAENDTDTDS
GYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGGGPGGGAAAA
AAALLGPDPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSPSAAA
AYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLS
PPPEKAGAAAATLLPHEVAPLGAPHPQHPHGRTHLPFAGPREPGNPESSAQEDPSQPGKE
AP
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element. May also function in the P53-signaling pathway.
Uniprot ID
Q9C0K0
Ensemble ID
ENST00000345514.2
HGNC ID
HGNC:13222

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.S483L .
A375 SNV: p.V690M .
COLO792 SNV: p.G207R .
HCC15 SNV: p.C185Ter .
HEC1 SNV: p.F431L; p.A583T .
HEC1B SNV: p.A583T .
IGROV1 SNV: p.D362G .
JURKAT SNV: p.H479Y Compound 10    Probe Info 
KMCH1 SNV: p.S744W .
MCC26 SNV: p.P670L .
MOLT4 SNV: p.K617E IA-alkyne    Probe Info 
NALM6 SNV: p.R822Q DBIA    Probe Info 
NCIH2172 SNV: p.H528N .
OVTOKO SNV: p.T840M .
RL952 SNV: p.V444M; p.W876R .
SKMEL24 SNV: p.G648S .
SKMEL5 SNV: p.E504K .
SKOV3 SNV: p.D885V .
SNU1 Deletion: p.G656AfsTer67 .
SNU308 SNV: p.A233T .
TOV21G SNV: p.A606S; p.G847W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C808(1.76)  LDD3311  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		C808(0.00); C457(0.00); C460(0.00); C464(0.00)  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C808(0.00); C145(0.00); C457(0.00); C460(0.00)  LDD0037  [2]
Compound 10
 Probe Info  		C145(0.00); C88(0.00)  LDD2216  [3]
Compound 11
 Probe Info  		C145(0.00); C88(0.00)  LDD2213  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C808(0.88)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C808(0.92)  LDD1497  [4]
 LDCM0024  KB05 G361 C808(1.76)  LDD3311  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Histone deacetylase 2 (HDAC2) Histone deacetylase family Q92769

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402