Details of the Target

General Information of Target

Target ID LDTP11614
Target Name Dynein axonemal heavy chain 6 (DNAH6)
Gene Name DNAH6
Gene ID 1768
Synonyms
DNAHC6; DNHL1; HL2; KIAA1697; Dynein axonemal heavy chain 6; Axonemal beta dynein heavy chain 6; Ciliary dynein heavy chain 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMDSENKPENDEDEKINKEAQDLTKLSSHNEDGGPVSDVIASFPENSMGKRGFSESSNSD
SVVIGEDRNKHASKRRKLDEAEPLKSGKQGICRLETSESSVTEGGIALDETGKETFLSDC
TVGGTCLPNALSPSCNFSTIDVVSLKTDTEKTSAQEMVSLDLERESPFPPKEISVSCTIG
NVDTVLKCSICGHLFSSCSDLEKHAESHMQQPKEHTCCHCSHKAESSSALHMHIKQAHGP
QKVFSCDLCGFQCSEENLLNAHYLGKTHLRRQNLAARGGFVQILTKQPFPKKSRTMATKN
VHSKPRTSKSIAKNSDSKGLRNVGSTFKDFRGSISKQSGSSSELLVEMMPSRNTLSQEVE
IVEEHVTSLGLAQNPENQSRKLDTLVTSEGLLEKLESTKNTLQAAHGNSVTSRPRPERNI
LVLGNSFRRRSSTFTLKGQAKKRFNLLGIKRGTSETQRMYMKHLRTQMKTHDAESVLKHL
EACSSVQRVCVTTSETQEAEQGQGSARPPDSGLHSLTVKPASGSQTLCACTDCGQVATNR
TDLEIHVKRCHAREMKFYCRTCDFSSMSRRDLDEHLHSNQHQQTASVLSCQCCSFISLDE
INLRDHMKEKHNMHFLCTPCNLFFLSEKDVEEHKATEKHINSLVQPKTLQSSNSDLVLQT
LPLSTLESENAKESMDDSGKASQEEPLKSRVSHGNEVRHSSKPQFQCKKCFYKTRSSTVL
TRHIKLRHGQDYHFLCKACNLYSLSKEGMEKHIKRSKHLENAKKNNIGLSFEECIERVCI
GANDKKEEFDVSGNGRIEGHIGVQLQEHSYLEKGMLASEELSQSGGSTKDDELASTTTPK
RGRPKGNISRTCSHCGLLASSITNLTVHIRRKHSHQYSYLCKVCKYYTVTKGDMERHCAT
KKHKGRVEIEASGKHSSDIIVGPEGGSLEAGKKNAGSAVTMSDEHANKPAESPTSVLEKP
DRGNSIEAEVENVFHSLDGEVNSHLLDKKEQISSEPEDFAQPGDVYSQRDVTGTGENKCL
HCEFSAHSSASLELHVKRKHTKEFEFYCMACDYYAVTRREMTRHAATEKHKMKRQSYLNS
ANVEAGSADMSKNIIMPEEEHQQNSEEFQIISGQPSDTLKSRNAADCSILNENTNLDMSK
VLCAADSVEVETEEESNFNEDHSFCETFQQAPVKDKVRKPEEMMSLTMSSNYGSPSRFQN
ENSGSSALNCETAKKNHEISNDAGELRVHCEGEGGNAGDGGGVVPHRHLCPVTLDGERSA
ESPVLVVTRITREQGNLESGGQNRVARGHGLEDLKGVQEDPVLGNKEILMNSQHETEFIL
EEDGPASDSTVESSDVYETIISIDDKGQAMYSFGRFDSSIIRIKNPEDGELIDQSEEGLI
ATGVRISELPLKDCAQGVKKKKSEGSSIGESTRIRCDDCGFLADGLSGLNVHIAMKHPTK
EKHFHCLLCGKSFYTESNLHQHLASAGHMRNEQASVEELPEGGATFKCVKCTEPFDSEQN
LFLHIKGQHEELLREVNKYIVEDTEQINREREENQGNVCKYCGKMCRSSNSMAFLAHIRT
HTGSKPFKCKICHFATAQLGDARNHVKRHLGMREYKCHVCGVAFVMKKHLNTHLLGKHGV
GTPKERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTWPTCHYSFLTASAMKDHYRTH
TGEKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDECNFASTTQSHLTRHKRVHTGEK
PYRCPWCDYRSNCAENIRKHILHTGKHEGVKMYNCPKCDYGTNVPVEFRNHLKEQHPDIE
NPDLAYLHAGIVSKSYECRLKGQGATFVETDSPFTAAALAEEPLVKEKPLRSSRRPAPPP
EQVQQVIIFQGYDGEFALDPSVEETAAATLQTLAMAGQVARVVHITEDGQVIATSQSGAH
VGSVVPGPILPEQLADGATQVVVVGGSMEGHGMDESLSPGGAVIQQVTKQEILNLSEAGV
APPEASSALDALLCAVTELGEVEGRAGLEEQGRPGAKDVLIQLPGQEVSHVAADPEAPEI
QMFPQAQESPAAVEVLTQVVHPSAAMASQERAQVAFKKMVQGVLQFAVCDTAAAGQLVKD
GVTQVVVSEEGAVHMVAGEGAQIIMQEAQGEHMDLVESDGEISQIIVTEELVQAMVQESS
GGFSEGTTHYILTELPPGVQDEPGLYSHTVLETADSQELLQAGATLGTEAGAPSRAEQLA
SVVIYTQEGSSAAAAIQSQRESSELQEA
Target Bioclass
Other
Family
Dynein heavy chain family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Uniprot ID
Q9C0G6
Ensemble ID
ENST00000389394.8
HGNC ID
HGNC:2951

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.I783V .
A172 SNV: p.D3760Y .
CCK81 SNV: p.M2353L; p.Q2423R .
COLO792 SNV: p.E3129K; p.E3401K .
CORL88 SNV: p.W3607Ter .
DANG SNV: p.E2427K .
DETROIT562 SNV: p.Q1872K .
DU145 SNV: p.A2443V; p.D2726Y .
HCC44 SNV: p.E721Q .
HCC70 SNV: p.S800R .
HCT15 SNV: p.M452T .
HEC1B SNV: p.M1817I .
HGC27 SNV: p.P492S; p.K1787I .
HT115 SNV: p.E20K; p.D2363G; p.E3856K .
ICC10 SNV: p.F122V .
Ishikawa (Heraklio) 02 ER SNV: p.G1614Ter .
KARPAS299 SNV: p.S1266G .
KARPAS422 SNV: p.G3682A .
KMCH1 SNV: p.Q2470H .
KMS11 SNV: p.D2407N .
KPNYN SNV: p.A1486S .
KURAMOCHI SNV: p.S3634N .
KYSE410 SNV: p.Q1635Ter .
KYSE510 SNV: p.A607G .
L428 SNV: p.A859E .
LN229 SNV: p.P1118A .
MCC13 SNV: p.P2049L .
MDST8 SNV: p.D4028N .
MELHO Insertion: p.R3288PfsTer15 .
MEWO SNV: p.V2894M; p.T3999K .
MFE296 SNV: p.R2569C .
MFE319 SNV: p.A3001T .
MOLT4 Insertion: p.M2492NfsTer15
SNV: p.A1950V;p.A2821V		 .
NALM6 SNV: p.G1753R .
NCIH1155 SNV: p.K1589N .
NCIH1793 SNV: p.H3467L .
NCIH2291 SNV: p.E2701Q .
NCIH446 SNV: p.Q259P .
NUGC3 SNV: p.D3760E .
PC3 SNV: p.G1275V .
RVH421 SNV: p.K1185R .
SKMEL2 SNV: p.E2352K .
SKMEL24 SNV: p.I960S; p.M3875I .
SKMEL30 SNV: p.S523L; p.M3590I .
SKMEL5 SNV: p.P206S .
SNU1 SNV: p.T547A .
SW1116 SNV: p.G2994W .
UMUC3 SNV: p.S3592L .
YSCCC SNV: p.E2526K; p.E3701Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		N.A.  LDD0246  [1]
ATP probe
 Probe Info  		N.A.  LDD0035  [2]

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096