Details of the Target

General Information of Target

Target ID LDTP11592
Target Name Zinc finger homeobox protein 2 (ZFHX2)
Gene Name ZFHX2
Gene ID 85446
Synonyms
KIAA1056; KIAA1762; ZNF409; Zinc finger homeobox protein 2; Zinc finger homeodomain protein 2; ZFH-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSVTGAVLKTLLLLSTQNWNRVEAGNSYDCDDPLVSALPQASFSSSSELSSSHGPGFAR
LNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYLLMFSDSGWNW
KQYRQEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYR
SEVVDLDGKSSLLYRFDQKSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRAR
LFLLINSGEAKLPSTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGE
FNLMNLDYEISFGGIPAPGKSVSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQIIAMGNV
SFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLISGGIL
LFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLL
GPEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNFS
DLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSIYEQSCEAYKHR
GNTSGFYYIDSDGSGPLEPFLLYCNMTETAWTIIQHNGSDLTRVRNTNPENPYAGFFEYV
ASMEQLQATINRAEHCEQEFTYYCKKSRLVNKQDGTPLSWWVGRTNETQTYWGGSSPDLQ
KCTCGLEGNCIDSQYYCNCDADRNEWTNDTGLLAYKEHLPVTKIVITDTGRLHSEAAYKL
GPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIADFI
RIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKTQ
PAPADGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRG
HCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLL
SKNSSSHAASFHGDMKLSREMIKFSFRTTRTPSLLLFVSSFYKEYLSVIIAKNGSLQIRY
KLNKYQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDDNRRRQVHLSSGTEFSAVKS
LVLGRILEHSDVDQDTALAGAQGFTGCLSAVQLSHVAPLKAALHPSHPDPVTVTGHVTES
SCMAQPGTDATSRERTHSFADHSGTIDDREPLANAIKSDSAVIGGLIAVVIFILLCITAI
AVRIYQQKRLYKRSEAKRSENVDSAEAVLKSELNIQNAVNENQKEYFF
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli.
Uniprot ID
Q9C0A1
Ensemble ID
ENST00000419474.5
HGNC ID
HGNC:20152

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.E2120K .
AN3CA SNV: p.Q1006R; p.Y1876C .
CCK81 Insertion: p.G1813WfsTer23
SNV: p.L819P		 .
COLO320 SNV: p.T2411P .
DU145 SNV: p.C2151G .
EFO27 Deletion: p.P326LfsTer40; p.Q1803NfsTer3 .
HCT116 SNV: p.G324A .
HCT15 SNV: p.A118T; p.T1863A .
HEL SNV: p.D2061N .
HEL9217 SNV: p.D2061N .
HGC27 SNV: p.H18Q .
IGROV1 Insertion: p.D1429RfsTer22 .
LU65 SNV: p.A2509S .
MCC13 SNV: p.G79E .
MCC26 SNV: p.R1861H .
MEWO SNV: p.E1149K .
NCIH1993 SNV: p.K1930E .
NCIH716 SNV: p.T2411P .
OE33 SNV: p.P2486T .
RKO SNV: p.Q1362L .
SG231 SNV: p.M51I .
SKMEL30 SNV: p.G79E .
SKMEL5 SNV: p.Q1085Ter .
SNGM Deletion: p.V1924CfsTer6
SNV: p.A1391V		 .
SNU5 SNV: p.P1992T .
TOV21G SNV: p.L1634M .
UACC257 SNV: p.L2038Q; p.A2039G .
UACC62 SNV: p.G547E .
YSCCC SNV: p.Q1696H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1011(1.11); C1014(1.11)  LDD1492  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HEK-293T C1011(1.11); C1014(1.11)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C1011(0.96); C1014(0.96)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C1011(1.02); C1014(1.02)  LDD1502  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402