Details of the Target

General Information of Target

Target ID LDTP11574
Target Name Sialoadhesin (SIGLEC1)
Gene Name SIGLEC1
Gene ID 6614
Synonyms
SN; Sialoadhesin; Sialic acid-binding Ig-like lectin 1; Siglec-1; CD antigen CD169
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASGQFVNKLQEEVICPICLDILQKPVTIDCGHNFCLKCITQIGETSCGFFKCPLCKTSV
RKNAIRFNSLLRNLVEKIQALQASEVQSKRKEATCPRHQEMFHYFCEDDGKFLCFVCRES
KDHKSHNVSLIEEAAQNYQGQIQEQIQVLQQKEKETVQVKAQGVHRVDVFTDQVEHEKQR
ILTEFELLHQVLEEEKNFLLSRIYWLGHEGTEAGKHYVASTEPQLNDLKKLVDSLKTKQN
MPPRQLLEDIKVVLCRSEEFQFLNPTPVPLELEKKLSEAKSRHDSITGSLKKFKDQLQAD
RKKDENRFFKSMNKNDMKSWGLLQKNNHKMNKTSEPGSSSAGGRTTSGPPNHHSSAPSHS
LFRASSAGKVTFPVCLLASYDEISGQGASSQDTKTFDVALSEELHAALSEWLTAIRAWFC
EVPSS
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Subcellular location
Secreted; Cell membrane
Function
Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs)(). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2. Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination.; (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane.
Uniprot ID
Q9BZZ2
Ensemble ID
ENST00000344754.6
HGNC ID
HGNC:11127

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L868I .
COLO800 SNV: p.A773P .
HCT116 SNV: p.T703I .
HCT15 SNV: p.R946C
Substitution: p.D629_P630delinsEA		 .
HEC1 SNV: p.R1333S .
HT115 SNV: p.G448E .
HUPT3 SNV: p.L989H; p.L992Q .
IM95 SNV: p.L1224M .
JHH6 SNV: p.R929S .
JHH7 SNV: p.P1158S .
JURKAT SNV: p.A19V; p.T951I; p.P1284H .
KMCH1 SNV: p.C1613S .
KYSE30 SNV: p.Q1403E .
LS123 SNV: p.A1269P .
MEWO SNV: p.T645N;p.A1076V
Substitution: p.R1244C		 .
MFE280 SNV: p.A957V .
MOLT4 SNV: p.A837V; p.E1681D .
NCIH1993 SNV: p.R1333S .
NCIH23 SNV: p.S24C; p.H450Y; p.D1693V .
NCIH716 SNV: p.A1696V .
WM1552C SNV: p.G557C; p.P563H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Beta-d-glucose Small molecular drug DB02379
N-acetyl-alpha-neuraminic Acid Small molecular drug DB03721

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.