Details of the Target

General Information of Target

Target ID LDTP11554
Target Name UL16-binding protein 1 (ULBP1)
Gene Name ULBP1
Gene ID 80329
Synonyms
N2DL1; RAET1I; UL16-binding protein 1; ALCAN-beta; NKG2D ligand 1; N2DL-1; NKG2DL1; Retinoic acid early transcript 1I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAATKILLCLPLLLLLSGWSRAGRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKT
FLHYDCGNKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEPLT
LQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGARKMKEKWENDKVVAM
SFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPC
FILPGI
Target Bioclass
Other
Family
MHC class I family
Subcellular location
Cell membrane
Function Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Uniprot ID
Q9BZM6
Ensemble ID
ENST00000229708.4
HGNC ID
HGNC:14893

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C127(1.28)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Caov-3 C127(1.37)  LDD2295  [1]
 LDCM0023  KB03 A2780 C127(1.66)  LDD2671  [1]
 LDCM0024  KB05 IGR37 C127(1.28)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840