Details of the Target

General Information of Target

Target ID LDTP11553
Target Name UL16-binding protein 2 (ULBP2)
Gene Name ULBP2
Gene ID 80328
Synonyms
N2DL2; RAET1H; UL16-binding protein 2; ALCAN-alpha; NKG2D ligand 2; N2DL-2; NKG2DL2; Retinoic acid early transcript 1H
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAASPAILPRLAILPYLLFDWSGTGRADAHSLWYNFTIIHLPRHGQQWCEVQSQVDQK
NFLSYDCGSDKVLSMGHLEEQLYATDAWGKQLEMLREVGQRLRLELADTELEDFTPSGPL
TLQVRMSCECEADGYIRGSWQFSFDGRKFLLFDSNNRKWTVVHAGARRMKEKWEKDSGLT
TFFKMVSMRDCKSWLRDFLMHRKKRLEPTAPPTMAPGLAQPKAIATTLSPWSFLIILCFI
LPGI
Target Bioclass
Other
Family
MHC class I family
Subcellular location
Cell membrane
Function Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Uniprot ID
Q9BZM5
Ensemble ID
ENST00000367351.4
HGNC ID
HGNC:14894

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K116(5.14)  LDD3494  [1]
DBIA
 Probe Info  		C34(1.36)  LDD3375  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Heraklio 02 ER- C34(1.12)  LDD2401  [2]
 LDCM0023  KB03 Heraklio 02 ER- C34(1.28)  LDD2818  [2]
 LDCM0024  KB05 OE33 C34(1.36)  LDD3375  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Derlin-3 (DERL3) Derlin family Q96Q80
NKG2-D type II integral membrane protein (KLRK1) . P26718
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein YIPF6 (YIPF6) YIP1 family Q96EC8

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264