Details of the Target

General Information of Target

Target ID LDTP11527
Target Name Zinc finger protein GLIS2 (GLIS2)
Gene Name GLIS2
Gene ID 84662
Synonyms
NKL; Zinc finger protein GLIS2; GLI-similar 2; Neuronal Krueppel-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFTLLVLLSQLPTVTLGFPHCARGPKASKHAGEEVFTSKEEANFFIHRRLLYNRFDLELF
TPGNLERECNEELCNYEEAREIFVDEDKTIAFWQEYSAKGPTTKSDGNREKIDVMGLLTG
LIAAGVFLVIFGLLGYYLCITKCNRLQHPCSSAVYERGRHTPSIIFRRPEEAALSPLPPS
VEDAGLPSYEQAVALTRKHSVSPPPPYPGHTKGFRVFKKSMSLPSH
Target Bioclass
Transcription factor
Family
GLI C2H2-type zinc-finger protein family
Subcellular location
Nucleus speckle
Function
Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation.
Uniprot ID
Q9BZE0
Ensemble ID
ENST00000262366.7
HGNC ID
HGNC:29450

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C157(0.29)  LDD2236  [1]

References

1 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730