General Information of Target

Target ID LDTP11523
Target Name ATP-binding cassette sub-family A member 2 (ABCA2)
Gene Name ABCA2
Gene ID 20
Synonyms
ABC2; KIAA1062; ATP-binding cassette sub-family A member 2; EC 7.6.2.-; ATP-binding cassette transporter 2; ATP-binding cassette 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQ
IPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKT
LPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEE
CTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKFADTDKERTMRR
MQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQMA
ALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFAN
GIHPYPAQSPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPPMIPQQQREGPEG
CNLFIYHLPQEFGDAELMQMFLPFGFVSFDNPASAQTAIQAMNGFQIGMKRLKVQLKRPK
DANRPY
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCA family
Subcellular location
Endosome membrane
Function
Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation.
Uniprot ID
Q9BZC7
Ensemble ID
ENST00000341511.11
HGNC ID
HGNC:32

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C1070(1.73)  LDD3383  [1]
IA-alkyne
 Probe Info 
N.A.  LDD0165  [2]
IPM
 Probe Info 
N.A.  LDD2156  [3]
TFBX
 Probe Info 
N.A.  LDD0148  [4]
Acrolein
 Probe Info 
N.A.  LDD0217  [5]
NAIA_5
 Probe Info 
N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C1201(0.99)  LDD1508  [7]
 LDCM0277  AC18 HEK-293T C1201(0.93)  LDD1516  [7]
 LDCM0279  AC2 HEK-293T C1201(0.80)  LDD1518  [7]
 LDCM0286  AC26 HEK-293T C1201(0.94)  LDD1525  [7]
 LDCM0295  AC34 HEK-293T C1201(1.12)  LDD1534  [7]
 LDCM0304  AC42 HEK-293T C1201(1.17)  LDD1543  [7]
 LDCM0313  AC50 HEK-293T C1201(1.41)  LDD1552  [7]
 LDCM0321  AC58 HEK-293T C1201(1.12)  LDD1560  [7]
 LDCM0367  CL1 HEK-293T C2265(0.90)  LDD1571  [7]
 LDCM0370  CL101 HEK-293T C2265(1.04)  LDD1574  [7]
 LDCM0374  CL105 HEK-293T C2265(1.02)  LDD1578  [7]
 LDCM0378  CL109 HEK-293T C2265(1.08)  LDD1582  [7]
 LDCM0383  CL113 HEK-293T C2265(1.11)  LDD1587  [7]
 LDCM0387  CL117 HEK-293T C2265(0.97)  LDD1591  [7]
 LDCM0392  CL121 HEK-293T C2265(1.02)  LDD1596  [7]
 LDCM0396  CL125 HEK-293T C2265(0.96)  LDD1600  [7]
 LDCM0400  CL13 HEK-293T C2265(0.89)  LDD1604  [7]
 LDCM0405  CL18 HEK-293T C1201(1.17)  LDD1609  [7]
 LDCM0413  CL25 HEK-293T C2265(1.24)  LDD1617  [7]
 LDCM0419  CL30 HEK-293T C1201(0.99)  LDD1623  [7]
 LDCM0426  CL37 HEK-293T C2265(1.26)  LDD1630  [7]
 LDCM0432  CL42 HEK-293T C1201(1.11)  LDD1636  [7]
 LDCM0439  CL49 HEK-293T C2265(1.13)  LDD1643  [7]
 LDCM0445  CL54 HEK-293T C1201(1.13)  LDD1648  [7]
 LDCM0451  CL6 HEK-293T C1201(1.95)  LDD1654  [7]
 LDCM0453  CL61 HEK-293T C2265(1.07)  LDD1656  [7]
 LDCM0458  CL66 HEK-293T C1201(1.24)  LDD1661  [7]
 LDCM0466  CL73 HEK-293T C2265(1.05)  LDD1669  [7]
 LDCM0471  CL78 HEK-293T C1201(1.05)  LDD1674  [7]
 LDCM0479  CL85 HEK-293T C2265(0.89)  LDD1682  [7]
 LDCM0485  CL90 HEK-293T C1201(0.99)  LDD1688  [7]
 LDCM0492  CL97 HEK-293T C2265(1.11)  LDD1695  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 A2780 C1070(1.56)  LDD2254  [1]
 LDCM0023  KB03 A2780 C1070(1.91)  LDD2671  [1]
 LDCM0024  KB05 OVCAR-5 C1070(1.73)  LDD3383  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402