Details of the Target

General Information of Target

Target ID LDTP11522
Target Name CUGBP Elav-like family member 4 (CELF4)
Gene Name CELF4
Gene ID 56853
Synonyms
BRUNOL4; CUGBP Elav-like family member 4; CELF-4; Bruno-like protein 4; CUG-BP- and ETR-3-like factor 4; RNA-binding protein BRUNOL-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALSLEEEAGRIKDCWDNQEAPALSTCSNANIFRRINAILDNSLDFSRVCTTPINRGIHD
HLPDFQDSEETVTSRMLFPTSAQESSRGLPDANDLCLGLQSLSLTGWDRPWSTQDSDSSA
QSSTHSVLSMLHNPLGNVLGKPPLSFLPLDPLGSDLVDKFPAPSVRGSRLDTRPILDSRS
SSPSDSDTSGFSSGSDHLSDLISSLRISPPLPFLSLSGGGPRDPLKMGVGSRMDQEQAAL
AAVTPSPTSASKRWPGASVWPSWDLLEAPKDPFSIEREARLHRQAAAVNEATCTWSGQLP
PRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNMPKG
YVYLVFELEKSVRSLLQACSHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVR
SPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNN
QRSYLKAVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQVCFKYFCRSC
WHWRHSMEGLRHHSPLMRNQKNRDSS
Target Bioclass
Other
Family
CELF/BRUNOL family
Subcellular location
Nucleus
Function
RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.
Uniprot ID
Q9BZC1
Ensemble ID
ENST00000334919.9
HGNC ID
HGNC:14015

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.Q401Ter .
HEC1 SNV: p.V447M .
HGC27 SNV: p.Q401Ter .
MFE296 SNV: p.M241I .
MFE319 SNV: p.M218V .
PC9 SNV: p.H213L .
RPMI7951 SNV: p.C194G .
SBC5 SNV: p.N360S .
SKMEL2 SNV: p.V447M .
SNU423 SNV: p.P147T .
SUPT1 SNV: p.A108V .
U937 SNV: p.T320N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C63(2.16)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Kelly C63(1.17); C143(3.48)  LDD2417  [1]
 LDCM0023  KB03 Kelly C63(1.40); C143(3.16)  LDD2834  [1]
 LDCM0024  KB05 NB1 C63(2.16)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840