Details of the Target

General Information of Target

Target ID LDTP11517
Target Name Membrane-associated phosphatidylinositol transfer protein 2 (PITPNM2)
Gene Name PITPNM2
Gene ID 57605
Synonyms
KIAA1457; NIR3; Membrane-associated phosphatidylinositol transfer protein 2; Phosphatidylinositol transfer protein, membrane-associated 2; PITPnm 2; Pyk2 N-terminal domain-interacting receptor 3; NIR-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKAGRAGGPPPGGGAPWHLRNVLSDSVESSDDEFFDAREEMAEGKNAILIGMSQWNSND
LVEQIETMGKLDEHQGEGTAPCTSSILQEKQRELYRVSLRRQRFPAQGSIEIHEDSEEGC
PQRSCKTHVLLLVLHGGNILDTGAGDPSCKAADIHTFSSVLEKVTRAHFPAALGHILIKF
VPCPAICSEAFSLVSHLNPYSHDEGCLSSSQDHVPLAALPLLAISSPQYQDAVATVIERA
NQVYREFLKSSDGIGFSGQVCLIGDCVGGLLAFDAICYSAGPSGDSPASSSRKGSISSTQ
DTPVAVEEDCSLASSKRLSKSNIDISSGLEDEEPKRPLPRKQSDSSTYDCEAITQHHAFL
SSIHSSVLKDESETPAAGGPQLPEVSLGRFDFDVSDFFLFGSPLGLVLAMRRTVLPGLDG
FQVRPACSQVYSFFHCADPSASRLEPLLEPKFHLVPPVSVPRYQRFPLGDGQSLLLADAL
HTHSPLFLEGSSRDSPPLLDAPASPPQASRFQRPGRRMSEGSSHSESSESSDSMAPVGAS
RITAKWWGSKRIDYALYCPDVLTAFPTVALPHLFHASYWESTDVVAFILRQVMRYESVNI
KESARLDPAALSPANPREKWLRKRTQVKLRNVTANHRANDVIAAEDGPQVLVGRFMYGPL
DMVALTGEKVDILVMAEPSSGRWVHLDTEITNSSGRITYNVPRPRRLGVGVYPVKMVVRG
DQTCAMSYLTVLPRGMECVVFSIDGSFAASVSIMGSDPKVRPGAVDVVRHWQDLGYMILY
ITGRPDMQKQRVVSWLSQHNFPQGMIFFSDGLVHDPLRQKAIFLRNLMQECFIKISAAYG
STKDISVYSVLGLPASQIFIVGRPTKKYQTQCQFLSEGYAAHLAALEASHRSRPKKNNSR
MILRKGSFGLHAQPEFLRKRNHLRRTMSVQQPDPPAANPKPERAQSQPESDKDHERPLPA
LSWARGPPKFESVP
Target Bioclass
Transporter and channel
Family
PtdIns transfer protein family, PI transfer class IIA subfamily
Subcellular location
Endomembrane system
Function Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.
Uniprot ID
Q9BZ72
Ensemble ID
ENST00000280562.9
HGNC ID
HGNC:21044

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.R534Ter .
A498 SNV: p.E847Ter .
DU145 SNV: p.A681S .
HCT15 SNV: p.R209M .
HEC1B SNV: p.R83W .
JHH7 SNV: p.Q523H .
JURKAT SNV: p.P171A; p.R222W .
KPNYN SNV: p.A878S .
NCIH2122 SNV: p.S321P .
PC3 SNV: p.R991C .
RL952 SNV: p.R7W .
SKHEP1 SNV: p.G559E .
SKMEL28 SNV: p.N575T .
SW620 SNV: p.L769R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C752(1.82)  LDD3337  [1]
W1
 Probe Info  		K27(0.00); Y23(0.00)  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 DEL C101(2.84)  LDD2315  [1]
 LDCM0023  KB03 DEL C101(4.67)  LDD2732  [1]
 LDCM0024  KB05 MSTO-211H C752(1.82)  LDD3337  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.