Details of the Target

General Information of Target

Target ID LDTP11516
Target Name Membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3)
Gene Name PITPNM3
Gene ID 83394
Synonyms
NIR1; Membrane-associated phosphatidylinositol transfer protein 3; Phosphatidylinositol transfer protein, membrane-associated 3; PITPnm 3; Pyk2 N-terminal domain-interacting receptor 1; NIR-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGTEGSAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLPSLSAHELHRA
VREVLQLPDIALDVFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTSAPDDDVAMDE
PFLQFRRNVFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQL
GPYQPGRPAACDLREKLDSFLPAHLCKRGQSLFAALRGRGARAGPGEQGLLNAYRQVQEV
SSDGGCEAALGTHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVSVAISLEG
VHVIDSREKHVLLGLRFQELSWDHTSPEEEEPILWLEFDGDSEGTPVNKLLKIYSKQAEL
MSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTI
DYVEDGKGIRRVKPKRTTSFFSRQLSLGQGSYTVVQPGDSLEQG
Target Bioclass
Enzyme
Family
PtdIns transfer protein family, PI transfer class IIA subfamily
Subcellular location
Endomembrane system
Function Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.
Uniprot ID
Q9BZ71
Ensemble ID
ENST00000262483.13
HGNC ID
HGNC:21043

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.V850M .
AGS SNV: p.P425L .
HCT15 SNV: p.P81S; p.P939T .
HT115 SNV: p.D274N .
MDST8 SNV: p.D274Y .
NCIH1155 SNV: p.A190D .
OSRC2 SNV: p.P337L .
OVK18 SNV: p.A855P .
SNU1 SNV: p.P456L .
SNU5 SNV: p.A151P .
TOV21G SNV: p.A535E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K163(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C724(1.33)  LDD3353  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 COR-L88 C724(1.30)  LDD2311  [2]
 LDCM0023  KB03 COR-L88 C724(1.37)  LDD2728  [2]
 LDCM0024  KB05 NCI-H2052 C724(1.33)  LDD3353  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840