Details of the Target

General Information of Target

Target ID LDTP11497
Target Name Alanine--glyoxylate aminotransferase 2, mitochondrial (AGXT2)
Gene Name AGXT2
Gene ID 64902
Synonyms
AGT2; Alanine--glyoxylate aminotransferase 2, mitochondrial; AGT 2; EC 2.6.1.44; (R)-3-amino-2-methylpropionate--pyruvate transaminase; EC 2.6.1.40; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; EC 2.6.1.18; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPPRPAPSPPAPRRLDTSDVLQQIMAITDQSLDEAQARKHALNCHRMKPALFSVLCEI
KEKTVVSIRGIQDEDPPDAQLLRLDNMLLAEGVCRPEKRGRGGAVARAGTATPGGCPNDN
SIEHSDYRAKLSQIRQIYHSELEKYEQACREFTTHVTNLLQEQSRMRPVSPKEIERMVGA
IHGKFSAIQMQLKQSTCEAVMTLRSRLLDARRKRRNFSKQATEVLNEYFYSHLNNPYPSE
EAKEELARKGGLTISQVSNWFGNKRIRYKKNMGKFQEEATIYTGKTAVDTTEVGVPGNHA
SCLSTPSSGSSGPFPLPSAGDAFLTLRTLASLQPPPGGGCLQSQAQGSWQGATPQPATAS
PAGDPGSINSSTSN
Target Bioclass
Enzyme
Family
Class-III pyridoxal-phosphate-dependent aminotransferase family
Subcellular location
Mitochondrion
Function
Multifunctional aminotransferase with a broad substrate specifcity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Uniprot ID
Q9BYV1
Ensemble ID
ENST00000231420.11
HGNC ID
HGNC:14412

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 SNV: p.F381Y .
G402 SNV: p.M215L .
K562 SNV: p.E493Ter .
NCIH2170 SNV: p.N379H .
P31FUJ SNV: p.L30I .
RPMI8226 SNV: p.W334Ter .
SUDHL6 SNV: p.P492S .
T24 SNV: p.E175K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C241(1.80)  LDD3369  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 MCAS C241(1.75)  LDD2449  [1]
 LDCM0023  KB03 OAW-42 C241(2.17)  LDD2952  [1]
 LDCM0024  KB05 OAW-42 C241(1.80)  LDD3369  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840