Details of the Target

General Information of Target

Target ID LDTP11470
Target Name Zinc finger protein 341 (ZNF341)
Gene Name ZNF341
Gene ID 84905
Synonyms
Zinc finger protein 341
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLRAGGTLGRAGAGRGAPEGPGPSGGAQGGSIHSGRIAAVHNVPLSVLIRPLPSVLDPA
KVQSLVDTIREDPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRETIPAKLVQS
TLSDLRVYLGASTPDLQ
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription.
Uniprot ID
Q9BYN7
Ensemble ID
ENST00000342427.6
HGNC ID
HGNC:15992

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.D431G .
CHL1 SNV: p.V817I .
HCT15 SNV: p.P317L .
HEC1B SNV: p.N250Y .
HT115 SNV: p.A84G .
LNCaP clone FGC SNV: p.P768S .
LS123 SNV: p.V20A .
MCC13 SNV: p.G56E .
MFE296 Deletion: p.R754AfsTer11 .
MFE319 SNV: p.H570R .
MOLT4 SNV: p.P249S; p.S406N .
NCIH1993 SNV: p.A416S .
NCIH2172 SNV: p.I353V .
NUGC3 Deletion: p.P207LfsTer40 .
SUPT1 SNV: p.P31H .
TOV21G SNV: p.E619Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C756(20.00)  LDD2227  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C756(20.00)  LDD2227  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264