Details of the Target

General Information of Target

Target ID LDTP11451
Target Name Transmembrane protease serine 13 (TMPRSS13)
Gene Name TMPRSS13
Gene ID 84000
Synonyms
MSP; TMPRSS11; Transmembrane protease serine 13; EC 3.4.21.-; Membrane-type mosaic serine protease; Mosaic serine protease
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVTRDRAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILE
FAVGYLRERSRVEPPGVPRSPVQDAEALASCYLSGFRECLLRLAAFAHDASPAARAQLFS
ALHGYLRPKPPRPKPVDPRPPAPRPSLDPAAPALGPALHQRPPVHQGHPSPRCAWSPSLC
SPRAGDSGAPAPLTGLLPPPPPPHRQDGAPKAPLPPPPAFWRPWP
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Membrane
Function
Serine protease. Cleaves the proform of PRSS8/prostasin to form the active protein. Cleaves the proform of HGF to form the active protein which promotes MAPK signaling. Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos.
Uniprot ID
Q9BYE2
Ensemble ID
ENST00000430170.6
HGNC ID
HGNC:29808

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C211(1.09)  LDD2249  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0022  KB02 8505C C211(1.09)  LDD2249  [1]
 LDCM0023  KB03 8305C C211(1.79)  LDD2665  [1]
 LDCM0024  KB05 C-4-II C211(1.71)  LDD3116  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853