Details of the Target

General Information of Target

Target ID LDTP11424
Target Name Protein BEX2 (BEX2)
Gene Name BEX2
Gene ID 84707
Synonyms
Protein BEX2; Brain-expressed X-linked protein 2; hBex2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII
QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES
SKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH
Target Bioclass
Other
Family
BEX family
Subcellular location
Cytoplasm
Function
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates.
Uniprot ID
Q9BXY8
Ensemble ID
ENST00000372674.5
HGNC ID
HGNC:30933

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.A8V .
MCC26 SNV: p.M80I .
WM2664 Insertion: p.S44Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C47(0.89)  LDD1575  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0371  CL102 HEK-293T C47(0.89)  LDD1575  [1]
 LDCM0375  CL106 HEK-293T C47(0.87)  LDD1579  [1]
 LDCM0380  CL110 HEK-293T C47(0.83)  LDD1584  [1]
 LDCM0384  CL114 HEK-293T C47(0.53)  LDD1588  [1]
 LDCM0388  CL118 HEK-293T C47(1.01)  LDD1592  [1]
 LDCM0393  CL122 HEK-293T C47(0.82)  LDD1597  [1]
 LDCM0397  CL126 HEK-293T C47(0.91)  LDD1601  [1]
 LDCM0401  CL14 HEK-293T C47(1.04)  LDD1605  [1]
 LDCM0407  CL2 HEK-293T C47(0.89)  LDD1611  [1]
 LDCM0414  CL26 HEK-293T C47(0.93)  LDD1618  [1]
 LDCM0441  CL50 HEK-293T C47(0.80)  LDD1645  [1]
 LDCM0454  CL62 HEK-293T C47(1.13)  LDD1657  [1]
 LDCM0467  CL74 HEK-293T C47(0.84)  LDD1670  [1]
 LDCM0480  CL86 HEK-293T C47(1.08)  LDD1683  [1]
 LDCM0493  CL98 HEK-293T C47(0.80)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C47(0.88)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402