Details of the Target
General Information of Target
| Target ID | LDTP11411 | |||||
|---|---|---|---|---|---|---|
| Target Name | Testis-expressed protein 15 (TEX15) | |||||
| Gene Name | TEX15 | |||||
| Synonyms |
Testis-expressed protein 15; Cancer/testis antigen 42; CT42 |
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| 3D Structure | ||||||
| Sequence |
MSVKSPFNVMSRNNLEAPPCKMTEPFNFEKNENKLPPHESLRSPGTLPNHPNFRLKSSEN
GNKKNNFLLCEQTKQYLASQEDNSVSSNPNGINGEVVGSKGDRKKLPAGNSVSPPSAESN SPPKEVNIKPGNNVRPAKSKKLNKLVENSLSISNPGLFTSLGPPLRSTTCHRCGLFGSLR CSQCKQTYYCSTACQRRDWSAHSIVCRPVQPNFHKLENKSSIETKDVEVNNKSDCPLGVT KEIAIWAERIMFSDLRSLQLKKTMEIKGTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLK ETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLN RIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATKPLLMEQYCSIKIVDILEEEV VTFAVEVELPNSGKLLDHVLIEMGYGLKPSGQDSKKENADQSDPEDVGKMTTENNIVVDK SDLIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDF YPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLEL PMQAIKCVLAGVKPSLGIWTPEAICLMKKLVQNKIITVKVVDKLENSSLVELIDKSETPH VSVSKVLLDAGFAVGEQSMVTDKPSDVKETSVPLGVEGKVNPLEWTWVELGVDQTVDVVV CVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWY RALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHW SEEAITRFQMCVAGIKLQARVVEVTENGIGVELTDLSTCYPRIISDVLIDEHLVLKSASP HKDLPNDRLVNKHELQVHVQGLQATSSAEQWKTIELPVDKTIQANVLEIISPNLFYALPK GMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDV EVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQLIIMLLKNFML NQNVMLSVKGITKNVHTVSVEKCSENGTVDVADKLVTFGLAKNITPQRQSALNTEKMYRM NCCCTELQKQVEKHEHILLFLLNNSTNQNKFIEMKKLLKS |
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| Target Bioclass |
Other
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| Family |
TEX15 family
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| Subcellular location |
Cytoplasm
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| Function |
Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair. Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells. PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci. Not required for piRNA biosynthesis.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C709(3.37) | LDD3380 | [1] | |
|
BTD Probe Info |
 |
C988(0.81) | LDD2099 | [2] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0022 | KB02 | FU-OV-1 | C709(1.98) | LDD2328 | [1] |
| LDCM0023 | KB03 | A2780 | C709(2.22) | LDD2671 | [1] |
| LDCM0024 | KB05 | OV-90 | C709(3.37) | LDD3380 | [1] |
| LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C988(0.81) | LDD2099 | [2] |
| LDCM0518 | Nucleophilic fragment 22a | MDA-MB-231 | C988(0.67) | LDD2111 | [2] |
| LDCM0532 | Nucleophilic fragment 29a | MDA-MB-231 | C988(0.83) | LDD2125 | [2] |
| LDCM0534 | Nucleophilic fragment 30a | MDA-MB-231 | C988(0.68) | LDD2127 | [2] |
| LDCM0536 | Nucleophilic fragment 31 | MDA-MB-231 | C988(0.82) | LDD2129 | [2] |
| LDCM0546 | Nucleophilic fragment 40 | MDA-MB-231 | C988(0.79) | LDD2140 | [2] |
References