Details of the Target

General Information of Target

Target ID LDTP11354
Target Name Sorbin and SH3 domain-containing protein 1 (SORBS1)
Gene Name SORBS1
Gene ID 10580
Synonyms
KIAA0894; KIAA1296; SH3D5; Sorbin and SH3 domain-containing protein 1; Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSA
LAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNG
TSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEV
HNLDAKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGK
SKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCME
LLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQ
DADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARD
ELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKM
GITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQ
NSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAF
SDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNL
CATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELV
KTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVI
TIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWG
ALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRT
NIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPS
SIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT
PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKID
ATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPE
DTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH
IEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNKGMFPGFK
Target Bioclass
Other
Subcellular location
Cell junction, adherens junction
Function
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Uniprot ID
Q9BX66
Ensemble ID
ENST00000277982.9
HGNC ID
HGNC:14565

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.P1186L .
AN3CA SNV: p.H768R .
BICR22 SNV: p.S465L .
C4II SNV: p.S944Y .
COLO792 SNV: p.P910S .
DU145 SNV: p.K627R .
EOL1 SNV: p.A300T .
FADU SNV: p.I486T .
HCC15 SNV: p.G880A .
HT Deletion: p.E517DfsTer7 .
HT115 SNV: p.L314V .
HUH1 SNV: p.P157S .
IGROV1 Insertion: p.A1135GfsTer13 .
Ishikawa (Heraklio) 02 ER SNV: p.P1289L .
JHH7 SNV: p.P1009L .
KATOIII SNV: p.E319A .
NCIH446 SNV: p.T169A .
PF382 SNV: p.Y1240H .
SKHEP1 SNV: p.P1186S .
SKMM2 SNV: p.K347N; p.S1108R .
TOV21G SNV: p.S228Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y905(25.06)  LDD3495  [1]
HHS-475
 Probe Info  		Y869(0.87); Y922(0.94); Y831(1.11)  LDD0264  [2]
CY-1
 Probe Info  		Q807(0.00); Q815(0.00)  LDD0246  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y869(0.87); Y922(0.94); Y831(1.11)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y831(0.89); Y869(0.93); Y922(1.13)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y846(0.43); Y831(1.06); Y869(1.09); Y922(1.25)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y831(1.18); Y869(1.23); Y922(1.27)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y831(0.81); Y869(1.18); Y922(1.28); Y846(1.98)  LDD0268  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) Inositol 1,4,5-trisphosphate 5-phosphatase family O15357
Serine/threonine-protein kinase PAK 2 (PAK2) STE Ser/Thr protein kinase family Q13177
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) Zinc-containing alcohol dehydrogenase family Q8WWV3
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-7 (ATXN7) Ataxin-7 family O15265

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.