Details of the Target

General Information of Target

Target ID LDTP11352
Target Name Tapasin-related protein (TAPBPL)
Gene Name TAPBPL
Gene ID 55080
Synonyms
Tapasin-related protein; TAPASIN-R; TAP-binding protein-like; TAP-binding protein-related protein; TAPBP-R; Tapasin-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHTTQKDTTYTKIFVGGLPYHTTDASLRKYFEVFGEIEEAVVITDRQTGKSRGYGFVTMA
DRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQLHPALIQRPFGIPAH
YVYPQAFVQPGVVIPHVQPTAAAASTTPYIDYTGAAYAQYSAAAAAAAAAAAYDQYPYAA
SPAAAGYVTAGGYGYAVQQPITAAAPGTAAAAAAAAAAAAAFGQYQPQQLQTDRMQ
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function
Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC).
Uniprot ID
Q9BX59
Ensemble ID
ENST00000266556.8
HGNC ID
HGNC:30683

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.C115R; p.M216T .
HGC27 SNV: p.I93L .
HT1080 SNV: p.D44G .
Ishikawa (Heraklio) 02 ER SNV: p.Q182K .
MELJUSO SNV: p.L319F .
RKO SNV: p.D38Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C39(1.52)  LDD3325  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 UACC257 C39(1.62)  LDD2491  [1]
 LDCM0023  KB03 UACC257 C39(2.64)  LDD2908  [1]
 LDCM0024  KB05 UACC257 C39(1.52)  LDD3325  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840