Details of the Target

General Information of Target

Target ID LDTP11307
Target Name Specifically androgen-regulated gene protein (SARG)
Gene Name SARG
Gene ID 79098
Synonyms
C1orf116; Specifically androgen-regulated gene protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSQHSAAARPSSCRRKQEDDRDGLLAEREQEEAIAQFPYVEFTGRDSITCLTCQGTGYI
PTEQVNELVALIPHSDQRLRPQRTKQYVLLSILLCLLASGLVVFFLFPHSVLVDDDGIKV
VKVTFNKQDSLVILTIMATLKIRNSNFYTVAVTSLSSQIQYMNTVVSTYVTTNVSLIPPR
SEQLVNFTGKAEMGGPFSYVYFFCTVPEILVHNIVIFMRTSVKISYIGLMTQSSLETHHY
VDCGGNSTAI
Target Bioclass
Other
Family
SARG family
Subcellular location
Cytoplasm
Function Putative androgen-specific receptor.
Uniprot ID
Q9BW04
Ensemble ID
ENST00000359470.6
HGNC ID
HGNC:28667

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.T11LfsTer6 .
HT3 SNV: p.G512D .
MOLT4 SNV: p.P183S .
NCIH1792 SNV: p.Q422Ter .
OVK18 Deletion: p.C574VfsTer20 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C212(1.18)  LDD3316  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
IA-alkyne
 Probe Info  		C212(0.00); C338(0.00)  LDD0162  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 769-P C212(1.28)  LDD2246  [1]
 LDCM0023  KB03 769-P C212(0.95)  LDD2663  [1]
 LDCM0024  KB05 MEL167 C212(1.18)  LDD3316  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homer protein homolog 1 (HOMER1) Homer family Q86YM7
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060