Details of the Target

General Information of Target

Target ID LDTP11274
Target Name U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25)
Gene Name SNRNP25
Gene ID 79622
Synonyms
C16orf33; U11/U12 small nuclear ribonucleoprotein 25 kDa protein; U11/U12 snRNP 25 kDa protein; U11/U12-25K; Minus-99 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRKFLQRFLREGPNKT
GTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFLVQAKTYLGEEGKRVRNYFCCGLQ
DFTPEPDSYDVIWIQWVIGHLTDQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVD
SSVCRDLDVVRRIICSAGLSLLAEERQENLPDEIYHVYSFALR
Target Bioclass
Other
Subcellular location
Nucleus
Uniprot ID
Q9BV90
HGNC ID
HGNC:14161

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		N.A.  LDD2231  [1]
SF
 Probe Info  		N.A.  LDD0028  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LIM/homeobox protein Lhx4 (LHX4) . Q969G2
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Protein Mis18-beta (OIP5) Mis18 family O43482
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Cleavage and polyadenylation specificity factor subunit 7 (CPSF7) RRM CPSF6/7 family Q8N684
Tudor and KH domain-containing protein (TDRKH) Tdrkh family Q9Y2W6
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
PRKCA-binding protein (PICK1) . Q9NRD5
TNF receptor-associated factor 1 (TRAF1) . Q13077
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1

References

1 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
2 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931