Details of the Target

General Information of Target

Target ID LDTP11241
Target Name Programmed cell death protein 10 (PDCD10)
Gene Name PDCD10
Gene ID 11235
Synonyms
CCM3; TFAR15; Programmed cell death protein 10; Cerebral cavernous malformations 3 protein; TF-1 cell apoptosis-related protein 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLEAMAEPSPEDPPPTLKPETQPPEKRRRTIEDFNKFCSFVLAYAGYIPPSKEESDWPAS
GSSSPLRGESAADSDGWDSAPSDLRTIQTFVKKAKSSKRRAAQAGPTQPGPPRSTFSRLQ
APDSATLLEKMKLKDSLFDLDGPKVASPLSPTSLTHTSRPPAALTPVPLSQGDLSHPPRK
KDRKNRKLGPGAGAGFGVLRRPRPTPGDGEKRSRIKKSKKRKLKKAERGDRLPPPGPPQA
PPSDTDSEEEEEEEEEEEEEEMATVVGGEAPVPVLPTPPEAPRPPATVHPEGVPPADSES
KEVGSTETSQDGDASSSEGEMRVMDEDIMVESGDDSWDLITCYCRKPFAGRPMIECSLCG
TWIHLSCAKIKKTNVPDFFYCQKCKELRPEARRLGGPPKSGEP
Target Bioclass
Other
Family
PDCD10 family
Subcellular location
Cytoplasm
Function
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.
Uniprot ID
Q9BUL8
Ensemble ID
ENST00000392750.7
HGNC ID
HGNC:8761

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K164(7.04); K172(8.65); K179(7.08); K70(9.87)  LDD0277  [1]
ONAyne
 Probe Info  		K164(10.00)  LDD0275  [1]
Probe 1
 Probe Info  		Y152(8.97); Y154(32.93)  LDD3495  [2]
Acrolein
 Probe Info  		N.A.  LDD0223  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [5]
NHS
 Probe Info  		K70(0.00); K179(0.00)  LDD0010  [6]
1c-yne
 Probe Info  		N.A.  LDD0228  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phenylalanine--tRNA ligase alpha subunit (FARSA) Class-II aminoacyl-tRNA synthetase family Q9Y285
Serine/threonine-protein kinase 24 (STK24) STE Ser/Thr protein kinase family Q9Y6E0
Serine/threonine-protein kinase 25 (STK25) STE Ser/Thr protein kinase family O00506
Serine/threonine-protein kinase 26 (STK26) STE Ser/Thr protein kinase family Q9P289
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13) Protein-tyrosine phosphatase family Q12923
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cerebral cavernous malformations 2 protein (CCM2) CCM2 family Q9BSQ5
Protein FAM118B (FAM118B) FAM118 family Q9BPY3
Major intrinsically disordered Notch2-binding receptor 1 (MINAR1) MINAR family Q9UPX6
Striatin (STRN) WD repeat striatin family O43815
Uncharacterized protein C4orf19 (C4orf19) . Q8IY42

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.