Details of the Target

General Information of Target

Target ID LDTP11230
Target Name Spondin-2 (SPON2)
Gene Name SPON2
Gene ID 10417
Synonyms
DIL1; Spondin-2; Differentially expressed in cancerous and non-cancerous lung cells 1; DIL-1; Mindin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLFLALGSPWAVELPLCGRRTALCAAAALRGPRASVSRASSSSGPSGPVAGWSTGPSGAA
RLLRRPGRAQIPVYWEGYVRFLNTPSDKSEDGRLIYTGNMARAVFGVKCFSYSTSLIGLT
FLPYIFTQNNAISESVPLPIQIIFYGIMGSFTVITPVLLHFITKGYVIRLYHEATTDTYK
AITYNAMLAETSTVFHQNDVKIPDAKHVFTTFYAKTKSLLVNPVLFPNREDYIHLMGYDK
EEFILYMEETSEEKRHKDDK
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens. Binds bacterial lipopolysaccharide (LPS).
Uniprot ID
Q9BUD6
Ensemble ID
ENST00000290902.10
HGNC ID
HGNC:11253

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C171(1.22)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 DU145 C171(1.47)  LDD2318  [1]
 LDCM0023  KB03 DU145 C171(1.42)  LDD2735  [1]
 LDCM0024  KB05 IGR37 C171(1.22)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840