Details of the Target

General Information of Target

Target ID LDTP11201
Target Name RNA guanine-N7 methyltransferase activating subunit (RAMAC)
Gene Name RAMAC
Gene ID 83640
Synonyms
C15orf18; FAM103A1; RAMMET; RNA guanine-N7 methyltransferase activating subunit; Protein FAM103A1; RNA guanine-7 methyltransferase activating subunit; RNMT-activating mRNA cap methyltransferase subunit; RNMT-activating mini protein; RAM
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLARGHGDTAASTAAPLSEEGEVTSGLQALAVEDTGGPSASAGKAEDEGEGGREETERE
GSGGEEAQGEVPSAGGEEPAEEDSEDWCVPCSDEEVELPADGQPWMPPPSEIQRLYELLA
AHGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPVTPKDS
LIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEDPSPASPPL
RSSGSSLFPRQRKY
Target Bioclass
Other
Family
RAM family
Subcellular location
Nucleus
Function
Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA.
Uniprot ID
Q9BTL3
Ensemble ID
ENST00000304191.4
HGNC ID
HGNC:31022

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y91(1.17)  LDD0264  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y91(1.17)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y91(0.71)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y91(0.42)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y91(1.00)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y91(1.06)  LDD0268  [1]

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377