Details of the Target

General Information of Target

Target ID LDTP11170
Target Name N-alpha-acetyltransferase 11 (NAA11)
Gene Name NAA11
Gene ID 84779
Synonyms
ARD1B; ARD2; N-alpha-acetyltransferase 11; EC 2.3.1.255; N-terminal acetyltransferase complex ARD1 subunit homolog B; hARD2; NatA catalytic subunit Naa11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLDLEVVPERSLGNEQWEFTLGMPLAQAVAILQKHCRIIKNVQVLYSEQSPLSHDLILNL
TQDGIKLMFDAFNQRLKVIEVCDLTKVKLKYCGVHFNSQAIAPTIEQIDQSFGATHPGVY
NSAEQLFHLNFRGLSFSFQLDSWTEAPKYEPNFAHGLASLQIPHGATVKRMYIYSGNSLQ
DTKAPMMPLSCFLGNVYAESVDVLRDGTGPAGLRLRLLAAGCGPGLLADAKMRVFERSVY
FGDSCQDVLSMLGSPHKVFYKSEDKMKIHSPSPHKQVPSKCNDYFFNYFTLGVDILFDAN
THKVKKFVLHTNYPGHYNFNIYHRCEFKIPLAIKKENADGQTETCTTYSKWDNIQELLGH
PVEKPVVLHRSSSPNNTNPFGSTFCFGLQRMIFEVMQNNHIASVTLYGPPRPGSHLRTAE
LP
Target Bioclass
Enzyme
Family
Acetyltransferase family, ARD1 subfamily
Subcellular location
Cytoplasm
Function Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.
Uniprot ID
Q9BSU3
Ensemble ID
ENST00000286794.5
HGNC ID
HGNC:28125

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y145(0.93)  LDD0264  [1]
HHS-465
 Probe Info  		Y145(10.00)  LDD2237  [2]
Acrolein
 Probe Info  		N.A.  LDD0226  [3]
SF
 Probe Info  		N.A.  LDD0028  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y145(0.93)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y145(0.83)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y145(0.81)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y145(0.84)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y145(1.14)  LDD0268  [1]
 LDCM0109  NEM HeLa N.A.  LDD0226  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase EHMT2 (EHMT2) Histone-lysine methyltransferase family Q96KQ7
M-phase inducer phosphatase 1 (CDC25A) MPI phosphatase family P30304
Acetyl-coenzyme A thioesterase (ACOT12) . Q8WYK0
Mitochondrial amidoxime-reducing component 1 (MTARC1) . Q5VT66
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family Q96CW1
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CREB3 regulatory factor (CREBRF) BZIP family Q8IUR6
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 202 (ZNF202) . O95125
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sororin (CDCA5) Sororin family Q96FF9
Kinesin-associated protein 3 (KIFAP3) . Q92845

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931