Details of the Target

General Information of Target

Target ID LDTP11130
Target Name La-related protein 6 (LARP6)
Gene Name LARP6
Gene ID 55323
Synonyms
La-related protein 6; Acheron; Achn; La ribonucleoprotein domain family member 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDYRRLLMSRVVPGQFDDADSSDSENRDLKTVKEKDDILFEDLQDNVNENGEGEIEDEEE
EGYDDDDDDWDWDEGVGKLAKGYVWNGGSNPQANRQTSDSSSAKMSTPADKVLRKFENKI
NLDKLNVTDSVINKVTEKSRQKEADMYRIKDKADRATVEQVLDPRTRMILFKMLTRGIIT
EINGCISTGKEANVYHASTANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPR
KMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKA
RELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKD
CANVNDFFMRHSVAVMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHV
DEEVFKRAYIPRTLNEVKNYERDMDIIMKLKEEDMAMNAQQDNILYQTVTGLKKDLSGVQ
KVPALLENQVEERTCSDSEDIGSSECSDTDSEEQGDHARPKKHTTDPDIDKKERKKMVKE
AQREKRKNKIPKHVKKRKEKTAKTKKGK
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.
Uniprot ID
Q9BRS8
Ensemble ID
ENST00000299213.10
HGNC ID
HGNC:24012
ChEMBL ID
CHEMBL4739702

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P88L; p.K219T .
MFE319 SNV: p.V230M .
NCIH2172 SNV: p.G449C .
RKO Deletion: p.E238AfsTer4
SNV: p.P241L		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C406(42.95)  LDD0209  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0367  CL1 HEK-293T C378(0.93)  LDD1571  [4]
 LDCM0370  CL101 HEK-293T C378(1.04)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C378(0.97)  LDD1575  [4]
 LDCM0374  CL105 HEK-293T C378(0.91)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C378(1.09)  LDD1579  [4]
 LDCM0378  CL109 HEK-293T C378(1.11)  LDD1582  [4]
 LDCM0380  CL110 HEK-293T C378(1.42)  LDD1584  [4]
 LDCM0383  CL113 HEK-293T C378(1.27)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C378(1.03)  LDD1588  [4]
 LDCM0387  CL117 HEK-293T C378(1.09)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C378(1.03)  LDD1592  [4]
 LDCM0392  CL121 HEK-293T C378(1.11)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C378(0.74)  LDD1597  [4]
 LDCM0396  CL125 HEK-293T C378(0.89)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C378(1.17)  LDD1601  [4]
 LDCM0400  CL13 HEK-293T C378(1.23)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C378(0.81)  LDD1605  [4]
 LDCM0407  CL2 HEK-293T C378(1.29)  LDD1611  [4]
 LDCM0413  CL25 HEK-293T C378(1.01)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C378(1.27)  LDD1618  [4]
 LDCM0426  CL37 HEK-293T C378(0.96)  LDD1630  [4]
 LDCM0439  CL49 HEK-293T C378(0.97)  LDD1643  [4]
 LDCM0441  CL50 HEK-293T C378(1.08)  LDD1645  [4]
 LDCM0453  CL61 HEK-293T C378(1.08)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C378(1.13)  LDD1657  [4]
 LDCM0466  CL73 HEK-293T C378(1.08)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C378(1.36)  LDD1670  [4]
 LDCM0479  CL85 HEK-293T C378(0.94)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C378(0.75)  LDD1683  [4]
 LDCM0492  CL97 HEK-293T C378(1.17)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C378(1.52)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C378(1.61)  LDD1631  [4]
 LDCM0022  KB02 A204 C406(1.74)  LDD2252  [5]
 LDCM0023  KB03 Jurkat C406(42.95)  LDD0209  [1]
 LDCM0024  KB05 NCI-H1155 C406(4.03)  LDD3342  [5]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840