Details of the Target

General Information of Target

Target ID LDTP11122
Target Name Uridine diphosphate glucose pyrophosphatase NUDT22 (NUDT22)
Gene Name NUDT22
Gene ID 84304
Synonyms
Uridine diphosphate glucose pyrophosphatase NUDT22; UDPG pyrophosphatase; UGPPase; EC 3.6.1.45; Nucleoside diphosphate-linked moiety X motif 22; Nudix motif 22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASAPPPPDKLEGGGGPAPPPAPPSTGRKQGKAGLQMKSPEKKRRKSNTQGPAYSHLTE
FAPPPTPMVDHLVASNPFEDDFGAPKVGVAAPPFLGSPVPFGGFRVQGGMAGQVPPGYST
GGGGGPQPLRRQPPPFPPNPMGPAFNMPPQGPGYPPPGNMNFPSQPFNQPLGQNFSPPSG
QMMPGPVGGFGPMISPTMGQPPRAELGPPSLSQRFAQPGAPFGPSPLQRPGQGLPSLPPN
TSPFPGPDPGFPGPGGEDGGKPLNPPASTAFPQEPHSGSPAAAVNGNQPSFPPNSSGRGG
GTPDANSLAPPGKAGGGSGPQPPPGLVYPCGACRSEVNDDQDAILCEASCQKWFHRECTG
MTESAYGLLTTEASAVWACDLCLKTKEIQSVYIREGMGQLVAANDG
Target Bioclass
Enzyme
Family
Nudix hydrolase family
Function Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose.
Uniprot ID
Q9BRQ3
Ensemble ID
ENST00000279206.8
HGNC ID
HGNC:28189

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.Q188R .
HCT116 SNV: p.L201P .
JURKAT SNV: p.A66T .
MCC13 SNV: p.G122R .
OVK18 SNV: p.G165S .
SISO SNV: p.N195T .
SKOV3 SNV: p.T47I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K60(1.19)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270