Details of the Target

General Information of Target

Target ID LDTP11119
Target Name Transcription factor Ovo-like 2 (OVOL2)
Gene Name OVOL2
Gene ID 58495
Synonyms
ZNF339; Transcription factor Ovo-like 2; hOvo2; Zinc finger protein 339
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSVIFFACVVRVRDGLPLSASTDFYHTQDFLEWRRRLKSLALRLAQYPGRGSAEGCDFSI
HFSSFGDVACMAICSCQCPAAMAFCFLETLWWEFTASYDTTCIGLASRPYAFLEFDSIIQ
KVKWHFNYVSSSQMECSLEKIQEELKLQPPAVLTLEDTDVANGVMNGHTPMHLEPAPNFR
MEPVTALGILSLILNIMCAALNLIRGVHLAEHSLQVAHEEIGNILAFLVPFVACIFQCYL
YLFYSPARTMKVVLMLLFICLGNMYLHGLRNLWQILFHIGVAFLSSYQILTRQLQEKQSD
CGV
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function
Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos. Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Essential for brown/beige adipose tissue-mediated thermogenesis, is necessary for the development of brown adipocytes. In white adipose tissues, limits adipogenesis by blocking CEBPA binding to its transcriptional targets and inhibiting its transcription factor activity.
Uniprot ID
Q9BRP0
Ensemble ID
ENST00000278780.7
HGNC ID
HGNC:15804

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A673 SNV: p.Q202Ter .
HCT116 SNV: p.T168A .
LNCaP clone FGC SNV: p.Q186H DBIA    Probe Info 
LS180 SNV: p.E191A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C56(2.05)  LDD3364  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C140(0.74)  LDD2227  [2]
 LDCM0022  KB02 22RV1 C56(1.88)  LDD2243  [1]
 LDCM0023  KB03 AGS C56(2.24)  LDD2680  [1]
 LDCM0024  KB05 NCI-N87 C56(2.05)  LDD3364  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264