Details of the Target

General Information of Target

Target ID LDTP11112
Target Name Mesoderm posterior protein 1 (MESP1)
Gene Name MESP1
Gene ID 55897
Synonyms
BHLHC5; Mesoderm posterior protein 1; Class C basic helix-loop-helix protein 5; bHLHc5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTAAVPELKQISRVEAMRLGPGWSHSCHAMLYAANPGQLFGRIPMRFSVLMQMRFDGLL
GFPGGFVDRRFWSLEDGLNRVLGLGLGCLRLTEADYLSSHLTEGPHRVVAHLYARQLTLE
QLHAVEISAVHSRDHGLEVLGLVRVPLYTQKDRVGGFPNFLSNAFVSTAKCQLLFALKVL
NMMPEEKLVEALAAATEKQKKALEKLLPASS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways.
Uniprot ID
Q9BRJ9
Ensemble ID
ENST00000300057.5
HGNC ID
HGNC:29658

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264