Details of the Target

General Information of Target

Target ID LDTP11099
Target Name Sulfotransferase 4A1 (SULT4A1)
Gene Name SULT4A1
Gene ID 25830
Synonyms
SULTX3; Sulfotransferase 4A1; ST4A1; EC 2.8.2.-; Brain sulfotransferase-like protein; hBR-STL; hBR-STL-1; Nervous system sulfotransferase; NST
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPPDQCSQYMTSLLSPAVDDEKELQDMNAMVLSLTEEVKEEEEDAQPEPEQGTAAGEKL
KSAGAQGGEEKDGGGEEKDGGGAGVPGHLWEGDLEGTSGSDGNVEDSDQSEKEPGQQYSR
PQGAVGGLEPGNAQQPNVHAFTPLQLQELERIFQREQFPSEFLRRRLARSMNVTELAVQI
WFENRRAKWRRHQRALMARNMLPFMAVGQPVMVTAAEAITAPLFISGMRDDYFWDHSHSS
SLCFPMPPFPPPSLPLPLMLLPPMPPAGQAEFGPFPFVIVPSFTFPNV
Target Bioclass
Enzyme
Family
Sulfotransferase 1 family
Subcellular location
Cytoplasm
Function
Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS.
Uniprot ID
Q9BR01
Ensemble ID
ENST00000330884.9
HGNC ID
HGNC:14903
ChEMBL ID
CHEMBL1743298

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R147S .
CCK81 SNV: p.C237Y .
HCT15 SNV: p.C230Y .
MELHO SNV: p.L79F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C218(1.32)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCC15 C218(1.64)  LDD2340  [1]
 LDCM0023  KB03 Kelly C218(1.93)  LDD2834  [1]
 LDCM0024  KB05 NB1 C218(1.32)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840