Details of the Target

General Information of Target

Target ID LDTP11072
Target Name KxDL motif-containing protein 1 (KXD1)
Gene Name KXD1
Gene ID 79036
Synonyms
C19orf50; KxDL motif-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESMFSSPAEAALQRETGVPGLLTPLPDLDGVYELERVAGFVRDLGCERVALQFPDQLLG
DAVAVAARLEETTGSKMFILGDTAYGSCCVDVLGAEQAGAQALIHFGPACLSPPARPLPV
AFVLRQRSVALELCVKAFEAQNPDPKAPVVLLSEPACAHALEALATLLRPRYLDLLVSSP
AFPQPVGSLSPEPMPLERFGRRFPLAPGRRLEEYGAFYVGGSKASPDPDLDPDLSRLLLG
WAPGQPFSSCCPDTGKTQDEGARAGRLRARRRYLVERARDARVVGLLAGTLGVAQHREAL
AHLRNLTQAAGKRSYVLALGRPTPAKLANFPEVDVFVLLACPLGALAPQLSGSFFQPILA
PCELEAACNPAWPPPGLAPHLTHYADLLPGSPFHVALPPPESELWETPDVSLITGDLRPP
PAWKSSNDHGSLALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVTEAVSGRRGIA
IAYEDEGSG
Target Bioclass
Other
Family
KXD1 family
Subcellular location
Lysosome membrane
Function
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. May be involved in the biogenesis of lysosome-related organelles such as melanosomes.
Uniprot ID
Q9BQD3
Ensemble ID
ENST00000222307.9
HGNC ID
HGNC:28420

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AOyne
 Probe Info  		12.40  LDD0443  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) CMGC Ser/Thr protein kinase family Q92630
Myosin-7 (MYH7) Myosin family P12883
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Rab5 GDP/GTP exchange factor (RABGEF1) . Q9UJ41
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A) ATG8 family Q9H492
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Inhibitor of growth protein 5 (ING5) ING family Q8WYH8
Keratin, type II cuticular Hb1 (KRT81) Intermediate filament family Q14533
MOB kinase activator 1A (MOB1A) MOB1/phocein family Q9H8S9
Rho GDP-dissociation inhibitor 3 (ARHGDIG) Rho GDI family Q99819
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Tropomyosin alpha-1 chain (TPM1) Tropomyosin family P09493
Tropomyosin alpha-3 chain (TPM3) Tropomyosin family P06753
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
Elongin-A (ELOA) . Q14241
Intraflagellar transport protein 20 homolog (IFT20) . Q8IY31
Leucine-rich repeat-containing protein 45 (LRRC45) . Q96CN5
Microspherule protein 1 (MCRS1) . Q96EZ8
Renal cancer differentiation gene 1 protein (C4orf46) . Q504U0

References

1 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.