Details of the Target

General Information of Target

Target ID	LDTP11043
Target Name	Spindlin-2B (SPIN2B)
Gene Name	SPIN2B
Gene ID	474343
Synonyms	SPIN2; Spindlin-2B; Spindlin-like protein 2B; SPIN-2; SPIN-2B
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRR SEGLPSECRSVTD
Target Bioclass	Other
Family	SPIN/STSY family
Subcellular location	Nucleus
Function	Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors. Exhibits H3K4me3-binding activity.
Uniprot ID	Q9BPZ2
Ensemble ID	ENST00000275988.5
HGNC ID	HGNC:33147
ChEMBL ID	CHEMBL4523440

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
Acrolein Probe Info			N.A.	LDD0217	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Endophilin-B1 (SH3GLB1)				Endophilin family	Q9Y371

References

1	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.