General Information of Target

Target ID LDTP11032
Target Name Transcription cofactor vestigial-like protein 1 (VGLL1)
Gene Name VGLL1
Gene ID 51442
Synonyms
TDU; Transcription cofactor vestigial-like protein 1; Vgl-1; Protein TONDU
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDSRFRELRKRY
EDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRL
HRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQL
ELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMC
IGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDL
LAKDCHCI
Target Bioclass
Other
Family
Vestigial family
Subcellular location
Nucleus
Function May act as a specific coactivator for the mammalian TEFs.
Uniprot ID
Q99990
Ensemble ID
ENST00000370634.8
HGNC ID
HGNC:20985

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C177(4.25)  LDD3319  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ABC-1 C102(3.54); C177(3.15)  LDD2262  [1]
 LDCM0023  KB03 ABC-1 C102(5.43); C177(7.70)  LDD2679  [1]
 LDCM0024  KB05 MEWO C177(4.25)  LDD3319  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840