Details of the Target

General Information of Target

Target ID LDTP11031
Target Name Growth/differentiation factor 15 (GDF15)
Gene Name GDF15
Gene ID 9518
Synonyms
MIC1; PDF; PLAB; PTGFB; Growth/differentiation factor 15; GDF-15; Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE
SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD
KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA
SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSR
RGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIA
KYMETVKLLDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKTITKKRKK
EIEESKEPGVEDTEWSNTQTEEAIQTRSRTRKRVQK
Target Type
Clinical trial
Target Bioclass
Other
Family
TGF-beta family
Subcellular location
Secreted
Function
Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling.
TTD ID
T33245
Uniprot ID
Q99988
DrugMap ID
TT4MXVG
Ensemble ID
ENST00000252809.3
HGNC ID
HGNC:30142
ChEMBL ID
CHEMBL3120039

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C108(1.58); C222(0.91)  LDD3311  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C108(1.07); C68(1.17)  LDD2243  [1]
 LDCM0023  KB03 697 C108(1.52); C132(0.77)  LDD2662  [1]
 LDCM0024  KB05 G361 C108(1.58); C222(0.91)  LDD3311  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GDNF family receptor alpha-like (GFRAL) GDNFR family Q6UXV0
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Transforming acidic coiled-coil-containing protein 3 (TACC3) TACC family Q9Y6A5
Chromobox protein homolog 3 (CBX3) . Q13185

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264