Details of the Target

General Information of Target

Target ID LDTP11020
Target Name Endophilin-A1 (SH3GL2)
Gene Name SH3GL2
Gene ID 6456
Synonyms
CNSA2; SH3D2A; Endophilin-A1; EEN-B1; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP
NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES
MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD
EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL
KRRMREASSRPKREYKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRTPS
RSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV
EVLVPLPQ
Target Bioclass
Other
Family
Endophilin family
Subcellular location
Cytoplasm
Function
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Uniprot ID
Q99962
Ensemble ID
ENST00000380607.5
HGNC ID
HGNC:10831

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C108(110.93)  LDD0209  [1]
HHS-475
 Probe Info  		Y170(0.83)  LDD0264  [2]
HHS-465
 Probe Info  		Y170(8.36)  LDD2237  [3]
5E-2FA
 Probe Info  		H279(0.00); H147(0.00)  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0116  HHS-0101 DM93 Y170(0.83)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y170(1.03)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y170(0.70)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y170(1.04)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y170(1.06)  LDD0268  [2]
 LDCM0023  KB03 Jurkat C108(110.93)  LDD0209  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Tyrosine-protein phosphatase non-receptor type 23 (PTPN23) Protein-tyrosine phosphatase family Q9H3S7
Dynamin-2 (DNM2) Dynamin/Fzo/YdjA family P50570
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) . Q13444
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) . Q13443
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-2 (ATXN2) Ataxin-2 family Q99700
Endophilin-A1 (SH3GL2) Endophilin family Q99962
Endophilin-A2 (SH3GL1) Endophilin family Q99961
Endophilin-A3 (SH3GL3) Endophilin family Q99963
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) MRL family Q70E73
Emerin (EMD) . P50402
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) . Q96B97

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.