Details of the Target

General Information of Target

Target ID LDTP11017
Target Name Forkhead box protein C2 (FOXC2)
Gene Name FOXC2
Gene ID 2303
Synonyms
FKHL14; MFH1; Forkhead box protein C2; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; MFH-1 protein; Transcription factor FKH-14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRRGSLS
VRALLPGPPLQPPPPAPVLLYDQGGGRRRRGEAEAEAEEWEAESVLGTLLQKLREEGYLA
YYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVVGLGSLCLGSDCSDAESEADR
DSMSCGLDSEGATPPPVGLRASFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNL
PNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTV
TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEERHSQEQGSGGQA
SAASNPPSFFTTPTSDGAFELAPT
Target Type
Literature-reported
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcriptional activator.
TTD ID
T46092
Uniprot ID
Q99958
DrugMap ID
TTLBAP1
Ensemble ID
ENST00000649859.1
HGNC ID
HGNC:3801

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C75(1.76)  LDD3364  [1]
IPM
 Probe Info  		N.A.  LDD0025  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AGS C75(1.33)  LDD2263  [1]
 LDCM0023  KB03 AGS C75(1.34)  LDD2680  [1]
 LDCM0024  KB05 NCI-N87 C75(1.76)  LDD3364  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Forkhead box protein C2 (FOXC2) . Q99958
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin-associated protein 3-3 (KRTAP3-3) KRTAP type 3 family Q9BYR6
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255