General Information of Target

Target ID LDTP11013
Target Name Epidermal growth factor-like protein 8 (EGFL8)
Gene Name EGFL8
Gene ID 80864
Synonyms
C6orf8; NG3; Epidermal growth factor-like protein 8; EGF-like protein 8; Vascular endothelial statin-2; VE-statin-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLWPGAWMLLLLLFLLLLFLLPTLWFCSPSAKYFFKMAFYNGWILFLAVLAIPVCAVRG
RNVENMKILRLMLLHIKYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGR
CVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVMSEVAQTLLTQDVRVWVFPEGT
RNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYCKKERRFTSGQCQVRVLPPVPTE
GLTPDDVPALADRVRHSMLTVFREISTDGRGGGDYLKKPGGGG
Target Bioclass
Other
Subcellular location
Secreted
Uniprot ID
Q99944
Ensemble ID
ENST00000333845.11
HGNC ID
HGNC:13944

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C38(2.34)  LDD2253  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2058 C38(2.34)  LDD2253  [1]
 LDCM0023  KB03 A2058 C38(2.33)  LDD2670  [1]
 LDCM0024  KB05 A2058 C38(2.32)  LDD3087  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840