Details of the Target

General Information of Target

Target ID LDTP10980
Target Name Cell surface A33 antigen (GPA33)
Gene Name GPA33
Gene ID 10223
Synonyms
Cell surface A33 antigen; Glycoprotein A33
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGL
VIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLI
HNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDT
ANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACY
LTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPL
ATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMN
ERTSMNERETGML
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Subcellular location
Membrane
Function May play a role in cell-cell recognition and signaling.
TTD ID
T57001
Uniprot ID
Q99795
DrugMap ID
TT96HUR
Ensemble ID
ENST00000367868.4
HGNC ID
HGNC:4445
ChEMBL ID
CHEMBL3712927

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C43(1.76)  LDD3440  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC108 C43(1.70)  LDD2381  [1]
 LDCM0023  KB03 ICC108 C43(2.07)  LDD2798  [1]
 LDCM0024  KB05 SNU-245 C43(1.76)  LDD3440  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Uroplakin-2 (UPK2) Uroplakin-2 family O00526
Neurensin-1 (NRSN1) VMP family Q8IZ57
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MAL-like protein (MALL) MAL family Q13021
Neuronal vesicle trafficking-associated protein 1 (NSG1) NSG family P42857
Epithelial membrane protein 3 (EMP3) PMP-22/EMP/MP20 family P54852
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Protection of telomeres protein 1 (POT1) Telombin family Q9NUX5

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Krn-330 Antibody D07GNO
Mgd007 Monoclonal antibody D00PEN
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Hua33 Antibody D08IDB
Radiolabelled-hua33 Antibody D0LY0C

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853