Details of the Target

General Information of Target

Target ID LDTP10955
Target Name Collagen alpha-1(XII) chain (COL12A1)
Gene Name COL12A1
Gene ID 1303
Synonyms
COL12A1L; Collagen alpha-1(XII) chain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF
APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDV
NLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL
PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAI
IENPFLNGEVIRLDGAIRMQP
Target Bioclass
Other
Family
Fibril-associated collagens with interrupted helices (FACIT) family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.
Uniprot ID
Q99715
Ensemble ID
ENST00000322507.13
HGNC ID
HGNC:2188

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.R754Ter .
AN3CA Insertion: p.S661FfsTer13 DBIA    Probe Info 
AU565 SNV: p.S234C .
CCK81 SNV: p.G1131E; p.P3000H .
COLO320 SNV: p.Q2392E .
COLO800 SNV: p.E174K DBIA    Probe Info 
CORL88 SNV: p.D171H; p.V1967A; p.Y1968N DBIA    Probe Info 
DU145 SNV: p.S1411I; p.A1867T; p.S2871N .
EFO27 SNV: p.Y1061H DBIA    Probe Info 
HCC44 SNV: p.P2885A DBIA    Probe Info 
HCT15 SNV: p.V1218A; p.K2650N .
HEC1 SNV: p.T1448I DBIA    Probe Info 
HEC1B SNV: p.T1448I .
HGC27 SNV: p.S2994L .
HT SNV: p.T1469A .
HT115 SNV: p.G220W; p.K1094N; p.R1834W; p.E2165A; p.K2557N .
IGROV1 Deletion: p.N229IfsTer65 .
Ishikawa (Heraklio) 02 ER SNV: p.V1543I .
JM1 SNV: p.F2345L; p.A2385D .
KMS11 SNV: p.G126R .
KYSE180 SNV: p.F2132V DBIA    Probe Info 
KYSE30 SNV: p.P2856L .
MEC1 SNV: p.T387A .
MEWO SNV: p.R727Ter .
MOLT4 SNV: p.G799V .
NCIH196 Substitution: p.G2064F .
NCIH23 SNV: p.P2943T .
NCIH446 SNV: p.T3017A .
RH41 SNV: p.G2963E .
SHP77 SNV: p.G2809V .
SUPT1 SNV: p.R486L .
SW480 SNV: p.E344K .
SW756 SNV: p.Q183Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C431(2.01)  LDD3318  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0022  KB02 42-MG-BA C431(3.69)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C431(3.66)  LDD2661  [1]
 LDCM0024  KB05 MELHO C431(2.01)  LDD3318  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.