Details of the Target
General Information of Target
| Target ID | LDTP10944 | |||||
|---|---|---|---|---|---|---|
| Target Name | Fasciculation and elongation protein zeta-1 (FEZ1) | |||||
| Gene Name | FEZ1 | |||||
| Gene ID | 9638 | |||||
| Synonyms |
Fasciculation and elongation protein zeta-1; Zygin I; Zygin-1 |
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| 3D Structure | ||||||
| Sequence |
MARRYDELPHYPGIVDGPAALASFPETVPAVPGPYGPHRPPQPLPPGLDSDGLKREKDEI
YGHPLFPLLALVFEKCELATCSPRDGAGAGLGTPPGGDVCSSDSFNEDIAAFAKQVRSER PLFSSNPELDNLMIQAIQVLRFHLLELEKVHDLCDNFCHRYITCLKGKMPIDLVIEDRDG GCREDFEDYPASCPSLPDQNNMWIRDHEDSGSVHLGTPGPSSGGLASQSGDNSSDQGDGL DTSVASPSSGGEDEDLDQERRRNKKRGIFPKVATNIMRAWLFQHLSHPYPSEEQKKQLAQ DTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGAAFSPEGQPIGGYTETQPHVAVRPPG SVGMSLNLEGEWHYL |
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| Target Bioclass |
Other
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| Family |
Zygin family
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| Subcellular location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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| Function |
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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YN-1 Probe Info |
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N.A. | LDD0447 | [1] | |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Serine/threonine-protein kinase Nek1 (NEK1) | NEK Ser/Thr protein kinase family | Q96PY6 | |||
Transporter and channel
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Huntingtin (HTT) | Huntingtin family | P42858 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Centrosomal protein of 126 kDa (CEP126) | . | Q9P2H0 | |||
| Thioredoxin domain-containing protein 9 (TXNDC9) | . | O14530 | |||