Details of the Target

General Information of Target

Target ID LDTP10933
Target Name Oncostatin-M-specific receptor subunit beta (OSMR)
Gene Name OSMR
Gene ID 9180
Synonyms
OSMRB; Oncostatin-M-specific receptor subunit beta; Interleukin-31 receptor subunit beta; IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDKVEIEIAT
VMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLL
CTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLIS
EIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLH
HLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNP
INLSKTPQAYMCLPRLPVGSLV
Target Type
Literature-reported
Target Bioclass
Cytokine and receptor
Family
Type I cytokine receptor family, Type 2 subfamily
Subcellular location
Membrane
Function Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
TTD ID
T78567
Uniprot ID
Q99650
DrugMap ID
TTAH0KM
Ensemble ID
ENST00000274276.8
HGNC ID
HGNC:8507
ChEMBL ID
CHEMBL4630885

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.T888A .
GB1 SNV: p.M65I .
HT115 SNV: p.T10A .
IPC298 SNV: p.E136K .
JHH7 SNV: p.I782M .
MFE319 SNV: p.I555M .
NALM6 SNV: p.A610S .
NCIH146 SNV: p.G183W .
RKO SNV: p.G538D; p.C853Y .
SISO SNV: p.N836K .
SUPT1 SNV: p.V662I .
T98G SNV: p.A402T .
UACC62 SNV: p.S244F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K285(5.57)  LDD0277  [1]
BTD
 Probe Info  		C611(0.92)  LDD2125  [2]
IPM
 Probe Info  		C611(0.76)  LDD1702  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C611(0.76)  LDD1702  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C611(0.92)  LDD2125  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C611(1.25)  LDD2136  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) Complex I 49 kDa subunit family O75306
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) Complex I 75 kDa subunit family P28331
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase inhibitor, mitochondrial (ATP5IF1) ATPase inhibitor family Q9UII2
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
LIM/homeobox protein Lhx2 (LHX2) . P50458
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor family C group 5 member D (GPRC5D) G-protein coupled receptor 3 family Q9NZD1
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-6 receptor subunit beta (IL6ST) Type I cytokine receptor family P40189
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stress-70 protein, mitochondrial (HSPA9) Heat shock protein 70 family P38646
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255