Details of the Target

General Information of Target

Target ID LDTP10911
Target Name T-box transcription factor TBX5 (TBX5)
Gene Name TBX5
Gene ID 6910
Synonyms
T-box transcription factor TBX5; T-box protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR
DIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEK
ATTEADSTKKEEDASSCSDKVESLSDGSSHIAGDLPSDEDEGEDEKLNILPSKRDLAAEP
GNMWMRLPSDSAGIPQAGGEAEPHATAAGKTVASPCSSTESLSQRSVTSVRDSADVDCVL
DLSVKSSLSGVENLNSSYFSSQDVLRSNLVQVKVEKEASCDESDVGTNDYDMEHSTVKES
VSTNNRVQYEPAHLAPLREDSVLRELDREDKASDDEMMTPESERVQVEGGMESSLLPYVS
NILSPAGQIFMCPLCNKVFPSPHILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFS
CMYTLKRHERTHSGEKPYTCTQCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGD
LYRHIRKFHCELVNSLSVKSEALSLPTVRDWTLEDSSQELWK
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation . Binds to the core DNA motif of NPPA promoter.
Uniprot ID
Q99593
Ensemble ID
ENST00000310346.8
HGNC ID
HGNC:11604
ChEMBL ID
CHEMBL1687681

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BICR22 SNV: p.D25N .
CCK81 SNV: p.V267A .
HEC1 SNV: p.T72M .
Ishikawa (Heraklio) 02 ER SNV: p.K178R .
LOXIMVI SNV: p.A11T .
MCC13 SNV: p.S498F .
PC9 SNV: p.P465L .
RL952 SNV: p.R82W .
SNGM SNV: p.T283I .
SW1271 SNV: p.K226N .
TE1 SNV: p.P28S .
TE4 SNV: p.G33V .
WM115 SNV: p.G238S .
WM2664 SNV: p.G238S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		N.A.  LDD0273  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270