Details of the Target

General Information of Target

Target ID	LDTP10867
Target Name	Keratin, type I cytoskeletal 12 (KRT12)
Gene Name	KRT12
Gene ID	3859
Synonyms	Keratin, type I cytoskeletal 12; Cytokeratin-12; CK-12; Keratin-12; K12
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSL TPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAET HYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSR DDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGG AAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQR PNGAKAALVKSSMF
Target Bioclass	Other
Family	Intermediate filament family
Function	Involved in corneal epithelium organization, integrity and corneal keratin expression.
Uniprot ID	Q99456
Ensemble ID	ENST00000251643.5
HGNC ID	HGNC:6414

Probe(s) Labeling This Target

PAL-AfBPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
STS-2 Probe Info			N.A.	LDD0138	[1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved

Click To Hide/Show 2 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Griseofulvin				Small molecular drug	DB00400
Anthralin				.	DB11157

References

1	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.