Details of the Target

General Information of Target

Target ID LDTP10850
Target Name Granulocyte colony-stimulating factor receptor (CSF3R)
Gene Name CSF3R
Gene ID 1441
Synonyms
GCSFR; Granulocyte colony-stimulating factor receptor; G-CSF receptor; G-CSF-R; CD antigen CD114
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPG
RHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAG
EIVGEVRCHMEENQRVARRRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTAN
AESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLP
LLQQADELHRGDEQGKREGFQLLLNNKLVYGSRQDFLWRLARAYSDMCELTEEVSEKKSY
ALDGKEEAEAALEKGDESADCHLWYAVLCGQLAEHESIQRRIQSGFSFKEHVDKAIALQP
ENPMAHFLLGRWCYQVSHLSWLEKKTATALLESPLSATVEDALQSFLKAEELQPGFSKAG
RVYISKCYRELGKNSEARWWMKLALELPDVTKEDLAIQKDLEELEVILRD
Target Type
Successful
Target Bioclass
Cytokine and receptor
Family
Type I cytokine receptor family, Type 2 subfamily
Subcellular location
Secreted; Cell membrane
Function
Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.
TTD ID
T98913
Uniprot ID
Q99062
DrugMap ID
TTC70AJ
Ensemble ID
ENST00000373103.5
HGNC ID
HGNC:2439
ChEMBL ID
CHEMBL1996

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CMK SNV: p.D40N .
COLO679 SNV: p.R484T .
HCT15 SNV: p.E553K .
HEC1 SNV: p.G200C .
JURKAT SNV: p.S744F .
LNCaP clone FGC Insertion: p.S469QfsTer5 .
MDST8 SNV: p.E363V .
MELJUSO SNV: p.P286S .
MOLT4 SNV: p.D364Y .
OVK18 SNV: p.M231V .
RL952 SNV: p.Q110Ter .
SNU1 SNV: p.Q60R .
TKKK SNV: p.R64T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0175  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polyubiquitin-C (UBC) Ubiquitin family P0CG48

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Filgrastim BiotechDrug DB00099
Pegfilgrastim Small molecular drug D0AT8C
Eflapegrastim . DB15001
Lenograstim . DB13144
Lipegfilgrastim . DB13200
Tbo-filgrastim . D09WDK
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Peg-g-csf . D03ZAE
Phase 2
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Blz-945 Small molecular drug D08NDE
Ax-200 . D03GRD
Maxy-g34 . D05ZXS
Sbc-014 . D01LRM
Phase 1
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amg 820 . D0I8DX
Mk-6302 . D08YGY
Plx-5622 . D0W1YV
Plx7486 . D07PSL
Investigative
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Csl-324 Antibody D01QXW
Tg-3003 Antibody D0LD8U
Ac-710 Small molecular drug D0V4EX
N-(2-morpholinophenyl)-5-nitrofuran-2-carboxamide Small molecular drug D00WSN
Azd-7507 . D06CWM
Favid . DB05249
G-csf . D07CNF
Zp-g-csf . D02ILI
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zd-6003 . D0B6BQ

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060